| IL10 |
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| Наявні структури |
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| PDB | Пошук ортологів: PDBe RCSB |
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| Список кодів PDB | | 1ILK, 1INR, 1J7V, 1LK3, 1Y6K, 2ILK, 2H24 | | |
| Ідентифікатори |
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| Символи | IL10, CSIF, GVHDS, IL-10, IL10A, TGIF, interleukin 10 |
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| Зовнішні ІД | OMIM: 124092 MGI: 96537 HomoloGene: 478 GeneCards: IL10 |
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| Пов'язані генетичні захворювання |
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| синдром Бехчета, неспецифічний виразковий коліт[1] |
| Онтологія гена |
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| Молекулярна функція | • GO:0001948, GO:0016582 protein binding
• growth factor activity
• cytokine activity
• interleukin-10 receptor binding
• protein dimerization activity
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| Клітинна компонента | • extracellular region
• міжклітинний простір
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| Біологічний процес | • negative regulation of chronic inflammatory response to antigenic stimulus
• positive regulation of MHC class II biosynthetic process
• negative regulation of endothelial cell apoptotic process
• кровотворення
• negative regulation of interferon-gamma production
• regulation of sensory perception of pain
• positive regulation of B cell apoptotic process
• negative regulation of chemokine (C-C motif) ligand 5 production
• response to inactivity
• negative regulation of cytokine activity
• negative regulation of interleukin-1 production
• cellular response to hepatocyte growth factor stimulus
• cellular response to estradiol stimulus
• negative regulation of interleukin-6 production
• GO:0010260 старіння людини
• positive regulation of DNA-binding transcription factor activity
• negative regulation of apoptotic process
• GO:0002719 negative regulation of cytokine production involved in immune response
• response to glucocorticoid
• cytoplasmic sequestering of NF-kappaB
• negative regulation of interleukin-18 production
• negative regulation of MHC class II biosynthetic process
• response to activity
• response to organic substance
• response to carbon monoxide
• leukocyte chemotaxis
• type 2 immune response
• negative regulation of myeloid dendritic cell activation
• response to insulin
• negative regulation of interleukin-8 production
• response to lipopolysaccharide
• B cell proliferation
• negative regulation of T cell proliferation
• negative regulation of nitric oxide biosynthetic process
• branching involved in labyrinthine layer morphogenesis
• defense response to bacterium
• regulation of complement-dependent cytotoxicity
• GO:0046730, GO:0046737, GO:0046738, GO:0046736 імунна відповідь
• регуляція експресії генів
• B cell differentiation
• regulation of isotype switching
• negative regulation of tumor necrosis factor production
• negative regulation of membrane protein ectodomain proteolysis
• inflammatory response
• cellular response to lipopolysaccharide
• negative regulation of B cell proliferation
• negative regulation of inflammatory response
• GO:0032697 negative regulation of cytokine production
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• negative regulation of interleukin-12 production
• defense response to protozoan
• negative regulation of sensory perception of pain
• positive regulation of macrophage activation
• liver regeneration
• GO:1904739 regulation of synapse organization
• positive regulation of endothelial cell proliferation
• negative regulation of cell population proliferation
• negative regulation of heterotypic cell-cell adhesion
• positive regulation of heterotypic cell-cell adhesion
• positive regulation of cell cycle
• negative regulation of mitotic cell cycle
• endothelial cell apoptotic process
• regulation of response to wounding
• negative regulation of vascular associated smooth muscle cell proliferation
• positive regulation of vascular associated smooth muscle cell proliferation
• interleukin-12-mediated signaling pathway
• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• negative regulation of autophagy
• cytokine-mediated signaling pathway
• positive regulation of receptor signaling pathway via JAK-STAT
• positive regulation of pri-miRNA transcription by RNA polymerase II
• negative regulation of hydrogen peroxide-induced neuron death
• positive regulation of sprouting angiogenesis
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| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
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| Більше даних |
| Ортологи |
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| Види | Людина | Миша |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (мРНК) | | |
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| RefSeq (білок) | | |
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| Локус (UCSC) | Хр. 1: 206.77 – 206.77 Mb | Хр. 1: 130.95 – 130.95 Mb |
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| PubMed search | [2] | [3] |
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| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
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