Nordazepam

Nordazepam
Klinički podaci


Drugs.com	Monografija
Identifikatori
CAS broj	1088-11-5^Y
ATC kod	N05BA16 (WHO)
PubChem	CID 2997
DrugBank	none^Y
ChemSpider	2890^Y
UNII	67220MCM01^Y
KEGG	D08283^Y
ChEBI	CHEBI:111762^Y
ChEMBL	CHEMBL523^Y
Hemijski podaci
Formula	C₁₅H₁₁ClN₂O
Molarna masa	270,714
SMILES OC1=Nc2ccc(Cl)cc2C(=NC1)c3ccccc3
InChI InChI=1S/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)^Y Key:AKPLHCDWDRPJGD-UHFFFAOYSA-N^Y

Nordazepam je organsko jedinjenje, koje sadrži 15 atoma ugljenika i ima molekulsku masu od 270,714 Da.

Osobine

Osobina	Vrednost
Broj akceptora vodonika	3
Broj donora vodonika	1
Broj rotacionih veza	1
Particioni koeficijent^[1] (ALogP)	3,6
Rastvorljivost^[2] (logS, log(mol/L))	-5,0
Polarna površina^[3] (PSA, Å²)	45,0

^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.