AFDX-384
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| IUPAC ime | |
|---|---|
N-(2-[(2R)-2-[(dipropilamino)metil]piperidin-1-il]etil)-6-okso-5H-pirido[2,3-b][1,4]benzodiazepin-11-karboksamid | |
| Identifikatori | |
| CAS broj | 118290-27-0  Y |
| PubChem | CID 119357 |
| ChemSpider | 26233613 |
| Hemijski podaci | |
| Formula | C27H38N6O2 |
| Molarna masa | 478.628 g/mol |
SMILES
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InChI
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AFDX-384 (BIBN-161) je lek koji deluje kao selektivni muskarinski acetilholinski antagonist, sa selektivnošću za M2 i M4 podtipove. On se uglavnom koristi za mapiranje distribucije M2 i M4 muskarinskih receptora u mozgu, i studiranje njihovog učešća u razvoju i tretmanu demencije i šizofrenije.[1][2][3][4][5][6][7]
Reference
- ^ Tränkle C, Andresen I, Lambrecht G, Mohr K (1998). „M2 receptor binding of the selective antagonist AF-DX 384: possible involvement of the common allosteric site”. Molecular Pharmacology. 53 (2): 304—12. PMID 9463489.
- ^ Kitaichi K, Day JC, Quirion R (1999). „A novel muscarinic M(4) receptor antagonist provides further evidence of an autoreceptor role for the muscarinic M(2) receptor sub-type”. European Journal of Pharmacology. 383 (1): 53—6. PMID 10556681. doi:10.1016/S0014-2999(99)00607-X.
- ^ Martin J, Deagostino A, Perrio C, Dauphin F, Ducandas C, Morin C, Desbène PL, Lasne MC (2000). „Syntheses of R and S isomers of AF-DX 384, a selective antagonist of muscarinic M2 receptors”. Bioorganic & Medicinal Chemistry. 8 (3): 591—600. PMID 10732976. doi:10.1016/S0968-0896(99)00307-7.
- ^ Piggott M, Owens J, O'Brien J, Paling S, Wyper D, Fenwick J, Johnson M, Perry R, Perry E (2002). „Comparative distribution of binding of the muscarinic receptor ligands pirenzepine, AF-DX 384, (R,R)-I-QNB and (R,S)-I-QNB to human brain”. Journal of Chemical Neuroanatomy. 24 (3): 211—23. PMID 12297267. doi:10.1016/S0891-0618(02)00066-2.
- ^ Zavitsanou K, Katsifis A, Yu Y, Huang XF (2005). „M2/M4 muscarinic receptor binding in the anterior cingulate cortex in schizophrenia and mood disorders”. Brain Research Bulletin. 65 (5): 397—403. PMID 15833594. doi:10.1016/j.brainresbull.2005.02.007.
- ^ Teaktong T, Piggott MA, Mckeith IG, Perry RH, Ballard CG, Perry EK (2005). „Muscarinic M2 and M4 receptors in anterior cingulate cortex: relation to neuropsychiatric symptoms in dementia with Lewy bodies”. Behavioural Brain Research. 161 (2): 299—305. PMID 15922057. doi:10.1016/j.bbr.2005.02.019.
- ^ Gibbons AS, Scarr E, McLean C, Sundram S, Dean B (2009). „Decreased muscarinic receptor binding in the frontal cortex of bipolar disorder and major depressive disorder subjects”. Journal of Affective Disorders. 116 (3): 184—91. PMC 2724602
. PMID 19103464. doi:10.1016/j.jad.2008.11.015.
Vidi još
- Pirenzepin (M1 selektivni antagonist)
- p
- r
- u
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 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
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