Kortikotropinu-sličan intermedijarni peptid

Kortikotropinu-sličan intermedijarni peptid
IUPAC ime
 
L-arginil-L-prolil-L-valil-L-lizil-L-valil-L-tirozil-L-prolil-L-asparaginil-L-glicil-L-alanil-L-α-glutamil-L-α-aspartil-L-α-glutamil-L-seril-L-alanil-L-α-glutamil-L-alanil-L-fenilalanil-L-prolil-L-leucil-L-α-glutamil-L-fenilalanin
Identifikacija
CAS registarski broj 53917-42-3
PubChem[1][2] 16133227
ChemSpider[3] 14195066
InChI

InChI=1S/C112H165N27O36/c1-56(2)48-72(100(163)125-70(37-41-86(148)149)97(160)133-77(111(174)175)51-63-24-14-11-15-25-63)129-103(166)79-28-20-46-138(79)109(172)75(49-62-22-12-10-13-23-62)131-93(156)61(9)121-95(158)68(35-39-84(144)145)123-92(155)60(8)122-102(165)78(55-140)134-98(161)71(38-42-87(150)151)126-101(164)74(53-88(152)153)128-96(159)69(36-40-85(146)147)124-91(154)59(7)120-83(143)54-119-94(157)73(52-82(115)142)130-104(167)80-29-21-47-139(80)110(173)76(50-64-31-33-65(141)34-32-64)132-107(170)89(57(3)4)135-99(162)67(27-16-17-43-113)127-106(169)90(58(5)6)136-105(168)81-30-19-45-137(81)108(171)66(114)26-18-44-118-112(116)117/h10-15,22-25,31-34,56-61,66-81,89-90,140-141H,16-21,26-30,35-55,113-114H2,1-9H3,(H2,115,142)(H,119,157)(H,120,143)(H,121,158)(H,122,165)(H,123,155)(H,124,154)(H,125,163)(H,126,164)(H,127,169)(H,128,159)(H,129,166)(H,130,167)(H,131,156)(H,132,170)(H,133,160)(H,134,161)(H,135,162)(H,136,168)(H,144,145)(H,146,147)(H,148,149)(H,150,151)(H,152,153)(H,174,175)(H4,116,117,118) DaY
Kod: ZYDMZKPAPSZILB-UHFFFAOYSA-N DaY

Svojstva
Molekulska formula C112H165N27O36
Molarna masa 2465,668 g/mol



Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

Kortikotropin-sličan intermedijarni peptid[4] (CLIP, adrenokortikotropni hormonski fragment 18-39, ACTH (18-39)) je prirodni endogeni neuropeptid sa dokozapeptidnom strukturom i aminokiselinskom sekvencom Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe. CLIP nastaje kao proizvod proteolitičkog razlaganja adrenokortikotropnog hormona (ACTH),[5][6] koji je produkt razlaganja proopiomelanokortina (POMC).[7] Mada ne izgleda da ima posebno važnu ulogu u telu,[8] on ima izvesna biološka dejstva,[9][10] posebno u neurološkim sistemima.[11][12][13][14][15]

Vidi još

  • Adrenokortikotropni hormon (ACTH)
  • Proopiomelanokortin (POMC)

Reference

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ↑ Silvana Andrić, Tatjana Kostić, Nebojša Andrić, Sonja Zorić (2006). Uporedna fiziologija životinja. Novi Sad: WUS Austria, Daniel Print. ISBN 86-7031-074-0. 
  5. ↑ Gianoulakis C, Seidah NG, Routhier R, Chrétien M (December 1979). „Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia”. The Journal of Biological Chemistry 254 (23): 11903–6. PMID 227883. Arhivirano iz originala na datum 2019-09-15. Pristupljeno 2014-04-11. 
  6. ↑ Fricker, Lloyd D. (24. 7. 1991.). Peptide biosynthesis and processing. CRC Press. str. 78. ISBN 978-0-8493-8852-1. Pristupljeno 25 November 2011. 
  7. ↑ Norman, Anthony W.; Litwack, Gerald (26. 9. 1997.). Hormones. Academic Press. str. 12. ISBN 978-0-12-521441-4. Pristupljeno 25 November 2011. 
  8. ↑ Larry Rex Engelking (1. 6. 2002.). Review of veterinary physiology. Teton NewMedia. str. 411. ISBN 978-1-893441-69-9. Pristupljeno 25 November 2011. 
  9. ↑ Marshall JB, Kapcala LP, Manning LD, McCullough AJ (November 1984). „Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules”. The Journal of Clinical Investigation 74 (5): 1886–9. DOI:10.1172/JCI111608. PMC 425369. PMID 6209301. 
  10. ↑ Zaphiropoulos A, Charnay Y, Vallet P, Constantinidis J, Bouras C (January 1991). „Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain”. Brain Research Bulletin 26 (1): 99–111. PMID 1849784. 
  11. ↑ Inoué, Shojiro; Inoué, Shojiro (1989). Biology of sleep substances. CRC Press. str. 136. ISBN 978-0-8493-4822-8. Pristupljeno 25 November 2011. 
  12. ↑ Chastrette N, Cespuglio R, Jouvet M (February 1990). „Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives”. Neuropeptides 15 (2): 61–74. PMID 1981927. 
  13. ↑ Chastrette N, Cespuglio R, Lin YL, Jouvet M (February 1990). „Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes”. Neuropeptides 15 (2): 75–88. PMID 1964203. 
  14. ↑ Grigoriev VV, Petrova LN, Ivanova TA, Gabreliyan AV, Serkova TP (March 2009). „Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain”. Bulletin of Experimental Biology and Medicine 147 (3): 319–22. PMID 19529852. 
  15. ↑ Seidenbecher T, Balschun D, Vogel D, Reymann KG (1993). „Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18-39)”]. Peptides 14 (6): 1221–4. PMID 8134304. 

Literatura

  • Inoué, Shojiro; Inoué, Shojiro (1989). Biology of sleep substances. CRC Press. str. 136. ISBN 978-0-8493-4822-8. Pristupljeno 25 November 2011. 
  • Larry Rex Engelking (2002). Review of veterinary physiology. Teton NewMedia. str. 411. ISBN 978-1-893441-69-9. Pristupljeno 25 November 2011. 
  • Norman, Anthony W.; Litwack, Gerald (1997). Hormones. Academic Press. str. 12. ISBN 978-0-12-521441-4. Pristupljeno 25 November 2011. 
  • Fricker, Lloyd D. (1991). Peptide biosynthesis and processing. CRC Press. str. 78. ISBN 978-0-8493-8852-1. Pristupljeno 25 November 2011. 

Spoljašnje veze

Portal Hemija
  • MeSH Corticotropin-Like+Intermediate+Lobe+Peptide
  • p
  • r
  • u
Endokrine
žlezde
Hipotalamusno-
hipofizni
α (FSH FSHB, LH LHB, TSH TSHB, CGA) • Prolaktin • POMC (CLIP, ACTH, MSH, Endorfini, Lipotropin) • GH
Druge endokrine
žlezde
Neendokrine
žlezde

M: END

anat/phys/devp/horm/cell

noco(d)/cong/tumr, sysi/epon

proc, lek (A10/H1/H2/H3/H5)

  • p
  • r
  • u
Hormoni
vidi hormoni
Opioidni peptidi
Drugi
Drugi neuropeptidi
Kinini
Neuromedini
B • N • S • U
Drugi
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)