Protein-coding gene in the species Homo sapiens
| ZACN |
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| Identifiers |
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| Aliases | ZACN, L2, LGICZ, LGICZ1, ZAC, ZAC1, Zinc-activated ion channel, zinc activated ion channel |
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| External IDs | OMIM: 610935 HomoloGene: 52296 GeneCards: ZACN |
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| Gene location (Human) |
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 | | Chr. | Chromosome 17 (human)[1] |
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| | Band | 17q25.1 | Start | 76,071,961 bp[1] |
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| End | 76,083,666 bp[1] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - Brodmann area 9
- anterior pituitary
- prefrontal cortex
- hypothalamus
- amygdala
- nucleus accumbens
- putamen
- caudate nucleus
- right lobe of thyroid gland
- ganglionic eminence
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| | | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - extracellular ligand-gated ion channel activity
- zinc ion binding
- ligand-gated ion channel activity
- ion channel activity
- serotonin-gated cation-selective channel activity
- transmembrane signaling receptor activity
| | Cellular component | - integral component of membrane
- plasma membrane
- membrane
- integral component of plasma membrane
- neuron projection
- synapse
| | Biological process | - response to zinc ion
- ion transport
- signal transduction
- ion transmembrane transport
- serotonin receptor signaling pathway
- chemical synaptic transmission
- regulation of membrane potential
- nervous system process
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 17: 76.07 – 76.08 Mb | n/a |
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| PubMed search | [2] | n/a |
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| Wikidata |
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Zinc-activated ion channel (ZAC), is a human protein encoded by the ZACN gene. ZAC forms a cation-permeable ligand-gated ion channel of the "Cys-loop" superfamily. The ZAC gene is present in humans and dogs, but no ortholog is thought to exist in the rat or mouse genomes.[3]
ZAC mRNA is expressed in prostate, thyroid, trachea, lung, brain (adult and fetal), spinal cord, skeletal muscle, heart, placenta, pancreas, liver, kidney and stomach.[3][4] The endogenous ligand for ZAC is thought to be Zn2+, although ZAC has also been found to activate spontaneously. The function of spontaneous ZAC activation is unknown.[3]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000186919 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c Davies PA, Wang W, Hales TG, Kirkness EF (January 2003). "A novel class of ligand-gated ion channel is activated by Zn2+". The Journal of Biological Chemistry. 278 (2): 712–7. doi:10.1074/jbc.M208814200. PMID 12381728.
- ^ Houtani T, Munemoto Y, Kase M, Sakuma S, Tsutsumi T, Sugimoto T (September 2005). "Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system". Biochemical and Biophysical Research Communications. 335 (2): 277–85. doi:10.1016/j.bbrc.2005.07.079. PMID 16083862.
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