Xenotropic and polytropic retrovirus receptor 1

Protein found in humans
XPR1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5IJH

Identifiers
AliasesXPR1, SYG1, X3, IBGC6, xenotropic and polytropic retrovirus receptor 1, SLC53A1
External IDsOMIM: 605237; MGI: 97932; HomoloGene: 134226; GeneCards: XPR1; OMA:XPR1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for XPR1
Genomic location for XPR1
Band1q25.3Start180,632,022 bp[1]
End180,890,279 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for XPR1
Genomic location for XPR1
Band1 G3|1 66.49 cMStart155,151,447 bp[2]
End155,293,161 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • myocardium of left ventricle

  • ganglionic eminence

  • secondary oocyte

  • endothelial cell

  • nasal epithelium

  • pancreatic epithelial cell

  • cardiac muscle tissue of right atrium

  • islet of Langerhans

  • Brodmann area 23

  • right ventricle
Top expressed in
  • median eminence

  • ventromedial nucleus

  • lateral septal nucleus

  • arcuate nucleus

  • habenula

  • ascending aorta

  • dorsomedial hypothalamic nucleus

  • extensor digitorum longus muscle

  • mammillary body

  • triceps brachii muscle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • transmembrane signaling receptor activity
  • phosphate ion transmembrane transporter activity
  • inositol hexakisphosphate binding
  • virus receptor activity
  • efflux transmembrane transporter activity
  • signaling receptor activity
Cellular component
  • integral component of membrane
  • membrane
  • intrinsic component of plasma membrane
  • plasma membrane
  • cytoplasm
  • Golgi apparatus
Biological process
  • viral entry into host cell
  • G protein-coupled receptor signaling pathway
  • response to virus
  • cellular phosphate ion homeostasis
  • phosphate ion transmembrane transport
  • phosphate ion transport
  • cellular response to phosphate starvation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9213

19775

Ensembl

ENSG00000143324

ENSMUSG00000026469

UniProt

Q9UBH6

Q9Z0U0

RefSeq (mRNA)

NM_004736
NM_001135669
NM_001328662

NM_011273

RefSeq (protein)

NP_001129141
NP_001315591
NP_004727

NP_035403

Location (UCSC)Chr 1: 180.63 – 180.89 MbChr 1: 155.15 – 155.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Xenotropic and polytropic retrovirus receptor 1 is a protein that in humans is encoded by the XPR1 gene. [5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143324 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026469 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Xenotropic and polytropic retrovirus receptor 1". Retrieved 2017-03-31.

Further reading

  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
  • Bhosle S, Suppiah S, Molinaro R, Liang Y, Arnold R, Diehl W, Makarova N, Blackwell J, Petros J, Liotta D, Hunter E, Ly H (2010). "Evaluation of cellular determinants required for in vitro xenotropic murine leukemia virus-related virus entry into human prostate cancer and noncancerous cells". J. Virol. 84 (13): 6288–96. doi:10.1128/JVI.00274-10. PMC 2903252. PMID 20410264.


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