TSEN15

Protein-coding gene in the species Homo sapiens

TSEN15

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2GW6

Identifiers

Aliases

TSEN15, C1orf19, sen15, tRNA splicing endonuclease subunit 15, PCH2F

External IDs

OMIM: 608756; MGI: 1913887; HomoloGene: 12002; GeneCards: TSEN15; OMA:TSEN15 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q25.3	Start	184,051,651 bp^[1]
Band	1q25.3	End	184,123,978 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1\|1 G2	Start	152,246,486 bp^[2]
Band	1\|1 G2	End	152,262,439 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

biceps brachii

vastus lateralis muscle

corpus epididymis

Brodmann area 46

deltoid muscle

gastrocnemius muscle

ganglionic eminence

substantia nigra

tibialis anterior muscle

Brodmann area 9

Top expressed in

yolk sac

quadriceps femoris muscle

olfactory bulb

placenta

heart

skeletal muscle tissue

lens

neural tube

hypothalamus

uterus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	tRNA-intron endonuclease activity nucleic acid binding nuclease activity
Cellular component	nucleolus nucleus nucleoplasm
Biological process	mRNA processing RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic tRNA processing tRNA splicing, via endonucleolytic cleavage and ligation nucleic acid phosphodiester bond hydrolysis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


116461


66637

Ensembl


ENSG00000198860


ENSMUSG00000014980

UniProt


Q8WW01


Q8R3W5

RefSeq (mRNA)


NM_001127394 NM_001300764 NM_001300766 NM_052965 NM_001363643


NM_025677

RefSeq (protein)


NP_001120866 NP_001287693 NP_001287695 NP_443197 NP_001350572


NP_079953

Location (UCSC)

Chr 1: 184.05 – 184.12 Mb

Chr 1: 152.25 – 152.26 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

tRNA-splicing endonuclease subunit Sen15 is an enzyme that in humans is encoded by the TSEN15 gene.^[5]^[6]^[7]

tRNA splicing is a fundamental process for cell growth and division. SEN15 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM]^[7]

Interactions

C1orf19 has been shown to interact with TSEN2.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198860 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000014980 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, et al. (April 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
^ Song J, Markley JL (February 2007). "Three-dimensional structure determined for a subunit of human tRNA splicing endonuclease (Sen15) reveals a novel dimeric fold". Journal of Molecular Biology. 366 (1): 155–64. doi:10.1016/j.jmb.2006.11.024. PMC 1865571. PMID 17166513.
^ ^a ^b "Entrez Gene: C1orf19 chromosome 1 open reading frame 19".
^ Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (April 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492. S2CID 16049289.