Sulfiram

Chemical compound

QS02QA02 (WHO)

Pharmacokinetic dataBioavailabilityVery lowExcretionRenal, unchangedIdentifiers

IUPAC name

N,N,N′,N′-tetraethyldicarbonotrithioic diamide

CAS Number

95-05-6

PubChem CID

7215

ChemSpider

6945

UNII

1XHL4Q8P7Y

KEGG

D08545

CompTox Dashboard (EPA)

DTXSID5058222

ECHA InfoCard100.002.171

Chemical and physical dataFormulaC₁₀H₂₀N₂S₃Molar mass264.46 g·mol⁻¹

Sulfiram (INN) or monosulfiram, trade name Tetmosol, is an ectoparasiticide used in the treatment and prevention of scabies.^[1] It is usually sold as a solution or medicated soap, sometimes in combination with benzyl benzoate.

Sulfiram is now rarely used, but, as of 2015^[update], is still available in Brazil, India, and South Africa (as monotherapy).^[1]

Adverse effects

Dizziness, headache, fatigue and erythematous rash may occur.^[2] A single case of toxic epidermal necrolysis was reported in 1968.^[3]

Sulfiram is structurally related to disulfiram (Antabuse), and readily converts to disulfiram when exposed to light. Like disulfiram, it can produce an unpleasant reaction when consumed with alcohol.^[1]^[4]

References

^ ^a ^b ^c Sweetman, Sean C., ed. (2009). "Pesticides and repellents". Martindale: the complete drug reference (36th ed.). London: Pharmaceutical Press. p. 2050. ISBN 978-0-85369-840-1.
^ [No authors listed] (2009). "Sarfiram - Bula". Bulário de Remédios Comerciais (in Portuguese). MedicinaNET. Retrieved 2010-08-11.
^ Copeman PW (March 1968). "Toxic epidermal necrolysis caused by skin hypersensitivity to monosulfiram". British Medical Journal. 1 (5592): 623–4. doi:10.1136/bmj.1.5592.623. PMC 1985336. PMID 5637574.
^ Mays DC, Nelson AN, Benson LM, Johnson KL, Naylor S, Lipsky JJ (November 1994). "Photolysis of sulfiram: a mechanism for its disulfiram-like reaction". Biochemical Pharmacology. 48 (10): 1917–25. doi:10.1016/0006-2952(94)90590-8. PMID 7986203.