Slow-reacting substance of anaphylaxis

LTC4
LTD4
LTE4

The slow-reacting substance of anaphylaxis or SRS-A is a mixture of the leukotrienes LTC4, LTD4 and LTE4. Mast cells secrete it during the anaphylactic reaction, inducing inflammation.[1] It can be found in basophils.

It induces prolonged, slow contraction of smooth muscle and has a major bronchoconstrictor role in asthma.[2] Compared to histamine, it is approximately 1000 times more potent and has a slower onset but longer duration of action.[citation needed]

References

  1. ^ "Dorland's Medical Dictionary". Archived from the original on January 9, 2007. Retrieved December 15, 2006.
  2. ^ Howard R. Morris; Graham W. Taylor; Priscilla J. Piper; John R. Tippins. "Structure of slow-reacting substance of anaphylaxis from guinea-pig lung". Retrieved December 15, 2006.

External links

  • Slow+Reacting+Substance+of+Anaphylaxis at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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Eicosanoids
Precursor
  • Arachidonic acid
Prostanoids
Prostaglandins (PG)
Precursor
  • H2
Active
D/J
  • D2
E/F
  • E2 (Dinoprostone)
  • E1 (Alprostadil)
  • F2α (Dinoprost):
I
  • I2 (Prostacyclin/Epoprostenol):
Thromboxanes (TX)
  • A2
  • B2
Leukotrienes (LT)
Precursor
Initial
  • A4
  • B4
SRS-A
  • C4
  • D4
  • E4
Eoxins (EX)
Precursor
  • Arachidonic acid 15-hydroperoxide
Eoxins
  • A4
  • C4
  • D4
  • E4
Nonclassic
By function
  • labor stimulation:
    • PGE2 (Dinoprostone)
    • PGF2α (Dinoprost)


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