SLITRK2

Protein-coding gene in the species Homo sapiens
SLITRK2
Identifiers
AliasesSLITRK2, CXorf2, SLITL1, SLIT and NTRK like family member 2, CXorf1, TMEM257
External IDsOMIM: 300561; MGI: 2679449; HomoloGene: 13054; GeneCards: SLITRK2; OMA:SLITRK2 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for SLITRK2
Genomic location for SLITRK2
BandXq27.3Start145,817,829 bp[1]
End145,829,856 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for SLITRK2
Genomic location for SLITRK2
BandX|X A7.1Start65,692,924 bp[2]
End65,704,999 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • internal globus pallidus

  • caudate nucleus

  • nucleus accumbens

  • ganglionic eminence

  • middle temporal gyrus

  • amygdala

  • putamen

  • dorsolateral prefrontal cortex

  • Brodmann area 9

  • prefrontal cortex
Top expressed in
  • trigeminal ganglion

  • substantia nigra

  • Region I of hippocampus proper

  • dentate gyrus

  • subiculum

  • primary motor cortex

  • habenula

  • olfactory tubercle

  • hippocampus proper

  • cerebellar vermis
More reference expression data
BioGPS




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

84631

245450

Ensembl

ENSG00000185985

ENSMUSG00000036790

UniProt

Q9H156

Q810C0

RefSeq (mRNA)
NM_001144003
NM_001144004
NM_001144005
NM_001144006
NM_001144007

NM_001144008
NM_001144009
NM_001144010
NM_032539

NM_001161431
NM_198863

RefSeq (protein)
NP_001137475
NP_001137476
NP_001137477
NP_001137478
NP_001137480

NP_001137481
NP_001137482
NP_115928

NP_001154903
NP_942563

Location (UCSC)Chr X: 145.82 – 145.83 MbChr X: 65.69 – 65.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SLIT and NTRK-like protein 2 is a protein that in humans is encoded by the SLITRK2 gene.[5][6][7]

Function

Members of the SLITRK family, such as SLITRK2, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK2, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity.[7][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185985 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036790 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (April 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
  6. ^ a b Aruga J, Yokota N, Mikoshiba K (October 2003). "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue". Gene. 315: 87–94. doi:10.1016/S0378-1119(03)00715-7. PMID 14557068.
  7. ^ a b "Entrez Gene: SLITRK2 SLIT and NTRK-like family, member 2".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.


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