SLC17A3

Protein-coding gene in the species Homo sapiens
SLC17A3
Identifiers
AliasesSLC17A3, NPT4, GOUT4, UAQTL4, solute carrier family 17 member 3
External IDsOMIM: 611034; MGI: 2389216; HomoloGene: 21319; GeneCards: SLC17A3; OMA:SLC17A3 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for SLC17A3
Genomic location for SLC17A3
Band6p22.2Start25,833,066 bp[1]
End25,882,286 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for SLC17A3
Genomic location for SLC17A3
Band13|13 A3.1Start24,023,417 bp[2]
End24,044,699 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • kidney tubule

  • kidney

  • right lobe of liver

  • glomerulus

  • metanephric glomerulus

  • renal medulla

  • right adrenal gland

  • left adrenal gland

  • ascending aorta

  • anterior pituitary
Top expressed in
  • kidney

  • proximal tubule

  • left lobe of liver

  • outer renal medulla

  • outer stripe of outer renal medulla

  • glomerulus

  • distal tubule

  • proximal straight tubule

  • proximal convoluted tubule

  • inner renal medulla
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • efflux transmembrane transporter activity
  • voltage-gated anion channel activity
  • xenobiotic transmembrane transporter activity
  • toxin transmembrane transporter activity
  • symporter activity
  • organic anion transmembrane transporter activity
  • sodium:phosphate symporter activity
  • urate transmembrane transporter activity
  • sialic acid transmembrane transporter activity
Cellular component
  • brush border membrane
  • integral component of membrane
  • perinuclear region of cytoplasm
  • membrane
  • endoplasmic reticulum
  • integral component of plasma membrane
  • plasma membrane
  • cytoplasm
  • endoplasmic reticulum membrane
  • apical plasma membrane
  • lysosome
Biological process
  • sodium ion transport
  • sodium ion transmembrane transport
  • ion transmembrane transport
  • glucose-6-phosphate transport
  • organic anion transport
  • urate metabolic process
  • phosphate ion transport
  • urate transport
  • ion transport
  • toxin transport
  • xenobiotic transmembrane transport
  • transmembrane transport
  • sialic acid transport
  • xenobiotic detoxification by transmembrane export across the plasma membrane
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10786

105355

Ensembl

ENSG00000124564

ENSMUSG00000036083

UniProt

O00476

n/a

RefSeq (mRNA)

NM_006632
NM_001098486

NM_001164743
NM_134069

RefSeq (protein)

NP_001091956
NP_006623

n/a

Location (UCSC)Chr 6: 25.83 – 25.88 MbChr 13: 24.02 – 24.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 17 (organic anion transporter), member 3 is a protein that in humans is encoded by the SLC17A3 gene.[5]

Function

The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124564 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036083 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Solute carrier family 17 (organic anion transporter), member 3".

Further reading

  • Polasek O, Jeroncić I, Mulić R, Klismanic Z, Pehlić M, Zemunik T, Kolcić I (2010). "Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series". Croat. Med. J. 51 (1): 32–9. doi:10.3325/cmj.2010.51.32. PMC 2829186. PMID 20162743.
  • Dehghan A, Köttgen A, Yang Q, Hwang SJ, Kao WL, Rivadeneira F, Boerwinkle E, Levy D, Hofman A, Astor BC, Benjamin EJ, van Duijn CM, Witteman JC, Coresh J, Fox CS (2008). "Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study". Lancet. 372 (9654): 1953–61. doi:10.1016/S0140-6736(08)61343-4. PMC 2803340. PMID 18834626.
  • Ruddy DA, Kronmal GS, Lee VK, Mintier GA, Quintana L, Domingo R, Meyer NC, Irrinki A, McClelland EE, Fullan A, Mapa FA, Moore T, Thomas W, Loeb DB, Harmon C, Tsuchihashi Z, Wolff RK, Schatzman RC, Feder JN (1997). "A 1.1-Mb transcript map of the hereditary hemochromatosis locus". Genome Res. 7 (5): 441–56. doi:10.1101/gr.7.5.441. PMID 9149941.
  • Jutabha P, Anzai N, Kitamura K, Taniguchi A, Kaneko S, Yan K, Yamada H, Shimada H, Kimura T, Katada T, Fukutomi T, Tomita K, Urano W, Yamanaka H, Seki G, Fujita T, Moriyama Y, Yamada A, Uchida S, Wempe MF, Endou H, Sakurai H (2010). "Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate". J. Biol. Chem. 285 (45): 35123–32. doi:10.1074/jbc.M110.121301. PMC 2966126. PMID 20810651.
  • Stark K, Reinhard W, Grassl M, Erdmann J, Schunkert H, Illig T, Hengstenberg C (2009). "Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease". PLOS ONE. 4 (11): e7729. Bibcode:2009PLoSO...4.7729S. doi:10.1371/journal.pone.0007729. PMC 2766838. PMID 19890391.
  • Jutabha P, Anzai N, Kimura T, Taniguchi A, Urano W, Yamanaka H, Endou H, Sakurai H (2011). "Functional analysis of human sodium-phosphate transporter 4 (NPT4/SLC17A3) polymorphisms". J. Pharmacol. Sci. 115 (2): 249–53. doi:10.1254/jphs.10228sc. PMID 21282933.
  • Melis D, Havelaar AC, Verbeek E, Smit GP, Benedetti A, Mancini GM, Verheijen F (2004). "NPT4, a new microsomal phosphate transporter: mutation analysis in glycogen storage disease type Ic". J. Inherit. Metab. Dis. 27 (6): 725–33. doi:10.1023/B:BOLI.0000045755.89308.2f. PMID 15505377. S2CID 20942710.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
  • t
  • e
Genetic disorder, membrane: Solute carrier disorders
1-1011-2021-4051-60
see also solute carrier family
  • v
  • t
  • e
By group
SLC1–10
(1):
(2):
(3):
(4):
(5):
(6):
(7):
(8):
  • Na+/Ca2+ exchanger
(9):
(10):
SLC11–20
(11):
(12):
(13):
(14):
(15):
(16):
(17):
(18):
(19):
(20):
SLC21–30
(21):
(22):
(23):
  • Na+-dependent ascorbic acid transporter
(24):
  • Na+/(Ca2+-K+) exchanger
(25):
(26):
(27):
(28):
(29):
(30):
SLC31–40
(31):
(32):
(33):
(34):
(35):
(36):
(37):
(38):
(39):
(40):
  • basolateral iron transporter
SLC41–48
(41):
(42):
(43):
  • Na+-independent, system-L like amino-acid transporter
(44):
(45):
(46):
(47):
(48):
SLCO1–4
Symporter, Cotransporter
  • Na+/K+,Cl−
  • Na+/Pi3
  • Na+/Cl−
  • Na+/glucose
  • Na+/I−
  • Cl−/K+
Antiporter (exchanger)
  • Na+/H+
  • Na+/Ca2+
    • Na+/(Ca2+-K+) - Cl−/HCO−
      3       (Band 3)
  • Cl−-formate
  • Cl−-oxalate
see also solute carrier disorders


Stub icon

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e