SHPRH

Protein-coding gene in the species Homo sapiens
SHPRH
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2M85, 4QN1

Identifiers
AliasesSHPRH, bA545I5.2, SNF2 histone linker PHD RING helicase, RAD5
External IDsOMIM: 608048; MGI: 1917581; HomoloGene: 6489; GeneCards: SHPRH; OMA:SHPRH - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for SHPRH
Genomic location for SHPRH
Band6q24.3Start145,864,245 bp[1]
End145,964,423 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for SHPRH
Genomic location for SHPRH
Band10|10 A1Start11,025,171 bp[2]
End11,093,339 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • testicle

  • pancreatic epithelial cell

  • sural nerve

  • retinal pigment epithelium

  • germinal epithelium

  • gonad

  • tibia

  • skin of thigh

  • bone marrow cells
Top expressed in
  • secondary oocyte

  • lobe of cerebellum

  • cerebellar vermis

  • primary oocyte

  • zygote

  • genital tubercle

  • lumbar subsegment of spinal cord

  • ganglionic eminence

  • trigeminal ganglion

  • ventricular zone
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • nucleotide binding
  • protein binding
  • hydrolase activity
  • ATP binding
  • helicase activity
  • metal ion binding
  • ubiquitin-protein transferase activity
  • ubiquitin protein ligase binding
  • transferase activity
  • ubiquitin protein ligase activity
Cellular component
  • nucleosome
  • nucleus
  • nucleoplasm
Biological process
  • nucleosome assembly
  • protein polyubiquitination
  • DNA repair
  • cellular response to DNA damage stimulus
  • protein ubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

257218

268281

Ensembl

ENSG00000146414

ENSMUSG00000090112

UniProt

Q149N8

Q7TPQ3

RefSeq (mRNA)

NM_001042683
NM_173082
NM_001370327
NM_001370328

NM_001077707
NM_001284354
NM_172937

RefSeq (protein)

NP_001036148
NP_775105
NP_001357256
NP_001357257

NP_001071175
NP_001271283
NP_766525

Location (UCSC)Chr 6: 145.86 – 145.96 MbChr 10: 11.03 – 11.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase SHPRH is an enzyme that in humans is encoded by the SHPRH gene.[5][6]

Function

SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases.[supplied by OMIM][6] SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146414 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090112 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sood R, Makalowska I, Galdzicki M, Hu P, Eddings E, Robbins CM, Moses T, Namkoong J, Chen S, Trent JM (August 2003). "Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region". Genomics. 82 (2): 153–61. doi:10.1016/S0888-7543(03)00121-6. PMID 12837266.
  6. ^ a b "Entrez Gene: SHPRH SNF2 histone linker PHD RING helicase".
  7. ^ Brühl, J; Trautwein, J; Schäfer, A; Linne, U; Bouazoune, K (21 August 2019). "The DNA repair protein SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase". Epigenetics & Chromatin. 12 (1): 52. doi:10.1186/s13072-019-0294-5. PMC 6702750. PMID 31434570.

Further reading

  • Motegi A, Sood R, Moinova H, Markowitz SD, Liu PP, Myung K (December 2006). "Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination". The Journal of Cell Biology. 175 (5): 703–8. doi:10.1083/jcb.200606145. PMC 2064669. PMID 17130289.
  • Unk I, Hajdú I, Fátyol K, Szakál B, Blastyák A, Bermudez V, Hurwitz J, Prakash L, Prakash S, Haracska L (November 2006). "Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen". Proceedings of the National Academy of Sciences of the United States of America. 103 (48): 18107–12. Bibcode:2006PNAS..10318107U. doi:10.1073/pnas.0608595103. PMC 1838714. PMID 17108083.
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" (PDF). Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
  • Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
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