SARS2

Protein-coding gene in the species Homo sapiens
SARS2
Identifiers
AliasesSARS2, SARS, SARSM, SERS, SYS, SerRS, SerRSmt, mtSerRS, seryl-tRNA synthetase 2, mitochondrial
External IDsOMIM: 612804; MGI: 1919234; HomoloGene: 6073; GeneCards: SARS2; OMA:SARS2 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for SARS2
Genomic location for SARS2
Band19q13.2Start38,915,266 bp[1]
End38,930,763 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for SARS2
Genomic location for SARS2
Band7 B1|7 16.91 cMStart28,441,417 bp[2]
End28,453,296 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • right lobe of liver

  • left adrenal gland

  • pituitary gland

  • right uterine tube

  • body of pancreas

  • anterior pituitary

  • prostate

  • minor salivary glands
Top expressed in
  • soleus muscle

  • yolk sac

  • maxillary prominence

  • thoracic diaphragm

  • intercostal muscle

  • skeletal muscle tissue

  • tibialis anterior muscle

  • proximal tubule

  • seminal vesicula

  • gastrocnemius muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • aminoacyl-tRNA ligase activity
  • nucleotide binding
  • ligase activity
  • ATP binding
  • serine-tRNA ligase activity
  • RNA binding
Cellular component
  • cytoplasm
  • mitochondrial matrix
  • mitochondrion
Biological process
  • tRNA aminoacylation for protein translation
  • protein biosynthesis
  • seryl-tRNA aminoacylation
  • selenocysteinyl-tRNA(Sec) biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54938

71984

Ensembl

ENSG00000104835
ENSG00000283104

ENSMUSG00000070699

UniProt

Q9NP81

Q9JJL8

RefSeq (mRNA)

NM_017827
NM_001145901

NM_023637

RefSeq (protein)

NP_001139373
NP_060297

NP_076126

Location (UCSC)Chr 19: 38.92 – 38.93 MbChr 7: 28.44 – 28.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Seryl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the SARS2 gene.[5][6]

References

  1. ^ a b c ENSG00000283104 GRCh38: Ensembl release 89: ENSG00000104835, ENSG00000283104 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070699 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yokogawa T, Shimada N, Takeuchi N, Benkowski L, Suzuki T, Omori A, Ueda T, Nishikawa K, Spremulli LL, Watanabe K (Aug 2000). "Characterization and tRNA recognition of mammalian mitochondrial seryl-tRNA synthetase". J Biol Chem. 275 (26): 19913–20. doi:10.1074/jbc.M908473199. PMID 10764807.
  6. ^ "Entrez Gene: SARS2 seryl-tRNA synthetase 2, mitochondrial".

Further reading

  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Müller T, Deschauer M, Neudecker S, Zierz S (2007). "Late-onset mitochondrial myopathy with dystrophic changes due to a G7497A mutation in the mitochondrial tRNA(Ser(UCN)) gene". Acta Neuropathol. 110 (4): 426–30. doi:10.1007/s00401-005-1063-z. PMID 16133542. S2CID 23568019.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ihalamulla RL, Liyanage CP, Karunaweera ND (2004). "A simple device to maintain in vitro cultures of Leishmania in tropical countries". Trans. R. Soc. Trop. Med. Hyg. 98 (5): 315–7. doi:10.1016/j.trstmh.2003.10.004. PMID 15109557.
  • Gibbons WJ, Yan Q, Li R, et al. (2004). "Genomic organization, expression, and subcellular localization of mouse mitochondrial seryl-tRNA synthetase". Biochem. Biophys. Res. Commun. 317 (3): 774–8. doi:10.1016/j.bbrc.2004.03.113. PMID 15081407.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Casas C, Ribera J, Esquerda JE (2001). "Antibodies against c-Jun N-terminal peptide cross-react with neo-epitopes emerging after caspase-mediated proteolysis during apoptosis". J. Neurochem. 77 (3): 904–15. doi:10.1046/j.1471-4159.2001.00314.x. PMID 11331419. S2CID 27427659.


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