RHOBTB1

Protein-coding gene in the species Homo sapiens
RHOBTB1
Identifiers
AliasesRHOBTB1, Rho related BTB domain containing 1
External IDsOMIM: 607351; MGI: 1916538; HomoloGene: 8892; GeneCards: RHOBTB1; OMA:RHOBTB1 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for RHOBTB1
Genomic location for RHOBTB1
Band10q21.2Start60,869,438 bp[1]
End61,001,440 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for RHOBTB1
Genomic location for RHOBTB1
Band10|10 B5.3Start68,987,264 bp[2]
End69,127,621 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • vastus lateralis muscle

  • Achilles tendon

  • biceps brachii

  • right uterine tube

  • placenta

  • cardia

  • triceps brachii muscle

  • gastrocnemius muscle

  • thoracic diaphragm

  • pylorus
Top expressed in
  • myocardium of ventricle

  • internal carotid artery

  • cumulus cell

  • aortic valve

  • ascending aorta

  • external carotid artery

  • ureter

  • islet of Langerhans

  • otolith organ

  • utricle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • GTP binding
  • GTPase activity
  • protein kinase binding
Cellular component
  • cytosol
  • plasma membrane
  • intracellular anatomical structure
  • cytoplasm
  • cytoskeleton
  • cell projection
Biological process
  • regulation of small GTPase mediated signal transduction
  • small GTPase mediated signal transduction
  • cell morphogenesis
  • actin filament organization
  • Rho protein signal transduction
  • cell migration
  • actin cytoskeleton organization
  • positive regulation of actin filament polymerization
  • actin cytoskeleton reorganization
  • engulfment of apoptotic cell
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9886

69288

Ensembl

ENSG00000072422

ENSMUSG00000019944

UniProt

O94844

Q9DAK3

RefSeq (mRNA)
NM_001242359
NM_014836
NM_001350902
NM_001350903
NM_001350904

NM_001350905
NM_001350906
NM_001350907
NM_001350908
NM_001350909
NM_001350910
NM_001350911

NM_001081347
NM_001252636
NM_001252637
NM_001252638

RefSeq (protein)
NP_001229288
NP_055651
NP_001337831
NP_001337832
NP_001337833

NP_001337834
NP_001337835
NP_001337836
NP_001337837
NP_001337838
NP_001337839
NP_001337840
NP_001229288.1
NP_055651.1

NP_001074816
NP_001239565
NP_001239566
NP_001239567

Location (UCSC)Chr 10: 60.87 – 61 MbChr 10: 68.99 – 69.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rho-related BTB domain-containing protein 1 is a protein that in humans is encoded by the RHOBTB1 gene.[5][6]

The protein encoded by this gene belongs to the Rho family of the Ras superfamily of small GTPases. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate transcriptional splice variants have been characterized.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000072422 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019944 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Rivero F, Dislich H, Glockner G, Noegel AA (Mar 2001). "The Dictyostelium discoideum family of Rho-related proteins". Nucleic Acids Res. 29 (5): 1068–79. doi:10.1093/nar/29.5.1068. PMC 29714. PMID 11222756.
  6. ^ a b "Entrez Gene: RHOBTB1 Rho-related BTB domain containing 1".

Further reading

  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. CiteSeerX 10.1.1.529.4378. doi:10.1093/dnares/5.5.277. PMID 9872452.
  • Ramos S, Khademi F, Somesh BP, Rivero F (2003). "Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse". Gene. 298 (2): 147–57. doi:10.1016/S0378-1119(02)00980-0. PMID 12426103.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Aspenström P, Fransson A, Saras J (2004). "Rho GTPases have diverse effects on the organization of the actin filament system". Biochem. J. 377 (Pt 2): 327–37. doi:10.1042/BJ20031041. PMC 1223866. PMID 14521508.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Beder LB, Gunduz M, Ouchida M, et al. (2006). "Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer" (PDF). J. Cancer Res. Clin. Oncol. 132 (1): 19–27. doi:10.1007/s00432-005-0033-0. PMID 16170569. S2CID 35193238.


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