Pamabrom

Pharmaceutical drug

none

Legal statusLegal status

US: OTC

Identifiers

IUPAC name

1:1 mixture of 2-amino-2-methyl-1-propanol and 8-bromotheophyllinate

CAS Number

606-04-2^Y

PubChem CID

11806

ChemSpider

11313^Y

UNII

UA8U0KJM72

ChEMBL

ChEMBL2104825^N

CompTox Dashboard (EPA)

DTXSID80209397

ECHA InfoCard100.009.186

Chemical and physical dataFormula8-Bromotheophylline: C₇H₇BrN₄O₂
2-Amino-2-methyl-1-propanol: C₄H₁₁NOMolar mass348.20 g/mol3D model (JSmol)

Interactive image

SMILES

Cn2c(=O)c1[nH]c(Br)nc1n(C)c2=O.NC(C)(C)CO

InChI

InChI=1S/C7H7BrN4O2.C4H11NO/c1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14;1-4(2,5)3-6/h1-2H3,(H,9,10);6H,3,5H2,1-2H3^Y
Key:ATOTUUBRFJHZQG-UHFFFAOYSA-N^Y

^NY (what is this?) (verify)

Pamabrom manufactured by Chattem Chemicals, and is a product included in retail drugs available in over-the-counter medications. The active diuretic ingredient in pamabrom is 8-bromotheophylline and it also contains aminoisobutanol.

Pamabrom is available in combination with acetaminophen (paracetamol) for various conditions such as back pain and menstrual relief.^[1] The acetaminophen helps reduce menstrual pains and the pamabrom reduces associated bloating. The combination is available in a number of products from various brands under different names. The dosages are essentially the same for each brand, including generic drug store varieties.

A diuretic is also used to reduce edema (fluid buildup) in the body. Edema can cause swelling of the extremities, such as in the hands and feet. Edema can make it harder for the heart to work properly, and it can be related to congestive heart failure.

References

^ Di Girolamo G, Sánchez AJ, De Los Santos AR, González CD (March 2004). "Is acetaminophen, and its combination with pamabrom, an effective therapeutic option in primary dysmenorrhoea?". Expert Opinion on Pharmacotherapy. 5 (3): 561–70. doi:10.1517/14656566.5.3.561. PMID 15013925. S2CID 26876035.