Nucleoporin 85

Protein-coding gene in the species Homo sapiens
NUP85
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5A9Q

Identifiers
AliasesNUP85, Nup75, FROUNT, nucleoporin 85, NPHS17
External IDsOMIM: 170285; MGI: 3046173; HomoloGene: 11755; GeneCards: NUP85; OMA:NUP85 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for NUP85
Genomic location for NUP85
Band17q25.1Start75,205,659 bp[1]
End75,235,758 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for NUP85
Genomic location for NUP85
Band11|11 E2Start115,455,260 bp[2]
End115,474,811 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar hemisphere

  • tibial nerve

  • right uterine tube

  • oocyte

  • canal of the cervix

  • right lobe of thyroid gland

  • skin of abdomen

  • left lobe of thyroid gland

  • upper lobe of left lung

  • left uterine tube
Top expressed in
  • fossa

  • condyle

  • primitive streak

  • Paneth cell

  • secondary oocyte

  • abdominal wall

  • morula

  • endocardial cushion

  • thymus

  • hair follicle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • structural constituent of nuclear pore
  • protein binding
Cellular component
  • cytoplasm
  • nuclear membrane
  • membrane
  • nuclear envelope
  • spindle
  • nuclear pore
  • chromosome
  • nuclear pore outer ring
  • chromosome, centromeric region
  • cytoskeleton
  • kinetochore
  • nucleus
  • cytosol
  • host cell
Biological process
  • mRNA transport
  • protein import into nucleus
  • viral transcription
  • protein sumoylation
  • positive regulation of transcription, DNA-templated
  • chemotaxis
  • mitotic nuclear membrane disassembly
  • macrophage chemotaxis
  • regulation of cellular response to heat
  • protein transport
  • viral process
  • lamellipodium assembly
  • intracellular transport of virus
  • mRNA export from nucleus
  • tRNA export from nucleus
  • sister chromatid cohesion
  • regulation of gene silencing by miRNA
  • regulation of glycolytic process
  • transport
  • nephron development
  • nucleocytoplasmic transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79902

445007

Ensembl

ENSG00000125450

ENSMUSG00000020739

UniProt

Q9BW27

Q8R480

RefSeq (mRNA)

NM_001303276
NM_024844
NM_001330472

NM_001002929

RefSeq (protein)

NP_001290205
NP_001317401
NP_079120

NP_001002929

Location (UCSC)Chr 17: 75.21 – 75.24 MbChr 11: 115.46 – 115.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleoporin 85 (Nup85) is a protein that in humans is encoded by the NUP85 gene.[5][6]

Function

Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP85 is part of one such subcomplex, Nup107-160.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125450 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020739 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Doxsey SJ, Stein P, Evans L, Calarco PD, Kirschner M (Feb 1994). "Pericentrin, a highly conserved centrosome protein involved in microtubule organization". Cell. 76 (4): 639–50. doi:10.1016/0092-8674(94)90504-5. PMID 8124707. S2CID 20503793.
  6. ^ a b "Entrez Gene: NUP85 nucleoporin 85kDa".

Further reading

  • Kapeller R, Toker A, Cantley LC, Carpenter CL (Oct 1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin". The Journal of Biological Chemistry. 270 (43): 25985–91. doi:10.1074/jbc.270.43.25985. PMID 7592789.
  • Tynan SH, Purohit A, Doxsey SJ, Vallee RB (Oct 2000). "Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin". The Journal of Biological Chemistry. 275 (42): 32763–8. doi:10.1074/jbc.M001536200. PMID 10893222.
  • Cronshaw JM, Krutchinsky AN, Zhang W, Chait BT, Matunis MJ (Sep 2002). "Proteomic analysis of the mammalian nuclear pore complex". The Journal of Cell Biology. 158 (5): 915–27. doi:10.1083/jcb.200206106. PMC 2173148. PMID 12196509.
  • Mulari MT, Patrikainen L, Kaisto T, Metsikkö K, Salo JJ, Väänänen HK (May 2003). "The architecture of microtubular network and Golgi orientation in osteoclasts--major differences between avian and mammalian species". Experimental Cell Research. 285 (2): 221–35. doi:10.1016/S0014-4827(03)00033-8. PMID 12706117.
  • Chang F, Re F, Sebastian S, Sazer S, Luban J (Apr 2004). "HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes". Molecular Biology of the Cell. 15 (4): 1793–801. doi:10.1091/mbc.E03-09-0691. PMC 379276. PMID 14767062.
  • Loïodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita JB, Doye V (Jul 2004). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Molecular Biology of the Cell. 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC 452587. PMID 15146057.
  • Terashima Y, Onai N, Murai M, Enomoto M, Poonpiriya V, Hamada T, Motomura K, Suwa M, Ezaki T, Haga T, Kanegasaki S, Matsushima K (Aug 2005). "Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis". Nature Immunology. 6 (8): 827–35. doi:10.1038/ni1222. PMID 15995708. S2CID 23496938.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Satoh M, Akatsu T, Ishkawa Y, Minami Y, Nakamura M (Mar 2007). "A novel activator of C-C chemokine, FROUNT, is expressed with C-C chemokine receptor 2 and its ligand in failing human heart". Journal of Cardiac Failure. 13 (2): 114–9. doi:10.1016/j.cardfail.2006.11.003. PMID 17395051.


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