Nifurzide
Chemical compound
- A07AX04 (WHO)
- 5-Nitro-N′-[(1E,2E)-3-(5-nitro-2-furyl)-2-propen-1-ylidene]-2-thiophenecarbohydrazide
- 39978-42-2
Y
- 9571044
- 7845510
- Z35R6K4C26
- D07251 Y
- Interactive image
- [O-][N+](=O)c1ccc(o1)/C=C/C=N/NC(=O)c2ccc(s2)[N+](=O)[O-]
InChI
- InChI=1S/C12H8N4O6S/c17-12(9-4-6-11(23-9)16(20)21)14-13-7-1-2-8-3-5-10(22-8)15(18)19/h1-7H,(H,14,17)/b2-1+,13-7+
- Key:IDUMOVRJNBNOTR-BIZLIJPVSA-N
Nifurzide is a nitrofuran derivative and intestinal anti-infectious agent active against Escherichia coli.[1]
References
- ^ Delsarte A, Faway M, Frère JM, Coyette J, Calberg-Bacq CM, Heinen E (March 1981). "Nifurzide, a nitrofuran antiinfectious agent: interaction with Escherichia coli cells". Antimicrobial Agents and Chemotherapy. 19 (3): 477–86. doi:10.1128/aac.19.3.477. PMC 181457. PMID 7018391.
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Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07)
- Oral rehydration therapy
- Charcoal
- Bismuth (including bismuth subsalicylate, known as Pepto-Bismol)
- Pectin
- Kaolin
- Crospovidone
- Attapulgite
- Diosmectite
- Opium tincture (laudanum)
- Codeine
- Morphine
- Camphorated opium tincture (paregoric)
- crosses BBB: Diphenoxylate (+atropine)
- Difenoxin
- does not cross BBB: Eluxadoline
- Loperamide# (+simethicone)
- corticosteroids acting locally
- antiallergic agents, excluding corticosteroids
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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