Mir-663 microRNA precursor family

mir-663
Identifiers
Symbol	mir-663
Rfam	RF00957
miRBase family	MIPF0000462
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

In molecular biology mir-663 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

Gastric cancer suppression

miR-663 has been identified as a possible suppressor of tumour growth, with its levels downregulated in human gastric cancer cell lines. Its introduction into the two human gastric cancer cell lines BGC823 and SNU5 induces morphology changes and suppresses cell proliferation.^[1] Transfection with miR-663 also sees a resultant upregulation of cyclin B.

miR-155 upregulation and other molecular targets

Resveratrol, a natural phenol and antioxidant, upregulates miR-663 in human THP-1 monocytic cells, human blood monocytes and MCF7 brest cancer cells.^[2] Endogenous activator protein-1 (AP-1) activity is decreased by miR-663 and there is additional impaired lipopolysaccharide upregulation. miR-663 directly targets JunD and JunB transcripts, and alters AP-1 upregulation through this. It is further involved in the impaired lipopolysaccharide upregulation of miR-155 by resveratrol.^[3] miR-663 also directly targets EEF1A2, translation elongation factor and well-known protooncogene.^[2]^[4]

References

^ Pan J, Hu H, Zhou Z, Sun L, Peng L, Yu L, Sun L, Liu J, Yang Z, Ran Y (July 2010). "Tumor-suppressive mir-663 gene induces mitotic catastrophe growth arrest in human gastric cancer cells". Oncology Reports. 24 (1): 105–12. doi:10.3892/or_00000834. PMID 20514450.
^ ^a ^b Vislovukh A, Kratassiouk G, Porto E, Gralievska N, Beldiman C, Pinna G, El'skaya A, Harel-Bellan A, Negrutskii B, Groisman I (June 2013). "Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744". British Journal of Cancer. 108 (11): 2304–11. doi:10.1038/bjc.2013.243. PMC 3681015. PMID 23695020.
^ Tili E, Michaille JJ, Adair B, Alder H, Limagne E, Taccioli C, Ferracin M, Delmas D, Latruffe N, Croce CM (September 2010). "Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD". Carcinogenesis. 31 (9): 1561–6. doi:10.1093/carcin/bgq143. PMC 4647642. PMID 20622002.
^ Anand N, Murthy S, Amann G, Wernick M, Porter LA, Cukier IH, Collins C, Gray JW, Diebold J, Demetrick DJ, Lee JM (July 2002). "Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer". Nature Genetics. 31 (3): 301–5. doi:10.1038/ng904. PMID 12053177. S2CID 37997742.

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