Microscopic Observation Drug Susceptibility assay
Microscopic Observation Drug Susceptibility assay | |
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Purpose | test for tuberculosis |
The Microscopic Observation Drug Susceptibility assay (MODS) is a culture method shown to be more sensitive, faster and cheaper test than current culture-based tests for Tuberculosis. The Microscopic Observation Drug Susceptibility assay (MODS) involves direct observation of Mycobacterium tuberculosis and simultaneously yields drug-resistance.
History of MODS
The discovery of the features of Mycobacterium tuberculosis growth detection which led to the development of MODS is attributed to Luz Caviedes working under the supervision of Bob Gilman in his laboratories at the Universidad Peruana Cayetano Heredia, Lima, Peru. The subsequent operational evaluation and refinement of the MODS methodology was the result of the combined effort of a coherent international research collaboration centred on Universidad Peruana Cayetano Heredia, Johns Hopkins Bloomberg School of Public Health and Imperial College London.[citation needed]
In partnership with the ongoing implementation of MODS in regional reference laboratories by the Peruvian National Reference Laboratory at the Instituto Nacional de Salud and the National TB Control Programme, this group is now leading the associated collaborative translational research (supported by the Wellcome Trust) which aims to answer the question “what is the optimal way to utilise MODS in a resource-limited programmatic setting?”[citation needed]
MODS is recommended by the WHO as an interim solution for developing countries who are waiting for the implementation of liquid culture methods.[1]
References
- ^ Minion J, Leung E, Menzies D, Pai M (2010). "Microscopic-observation drug susceptibility and thin layer agar assays for the detection of drug resistant tuberculosis: a systematic review and meta-analysis". Lancet Infect Dis. 10 (10): 688–698. doi:10.1016/S1473-3099(10)70165-1. PMID 20813587.
External links
- http://modsperu.org
- MODS article in NEJM 2006:
- v
- t
- e
associated conditions
- Pulmonary tuberculosis
- Ghon focus / Ghon's complex
- Extrapulmonary tuberculosis
- Caseous necrosis
- Pott disease
- Canga's bead symptom
- Prosector's wart
- Lupus vulgaris
- Tuberculous lymphadenitis
- Tuberculous meningitis
- Miliary tuberculosis
- Latent tuberculosis
- Paronychia
- Giant multinucleated cell
- Ziehl–Neelsen stain
- Auramine phenol stain
- Culture on Löwenstein–Jensen medium and/or MGIT
- Chest photofluorography
- GeneXpert MTB/RIF
- Interferon gamma release assay
- Microscopic Observation Drug Susceptibility assay
- Tuberculin
(ATC code J04)
- BCG vaccine
- Experimental
- Adirondack Cottage Sanitarium
- Campaign for Access to Essential Medicines
- Center for Global Infectious Disease Research
- Cure Cottages of Saranac Lake
- European and Developing Countries Clinical Trials Partnership
- Glen Lake Children's Camp
- Glen Lake Sanatorium
- Glenn Dale Hospital
- The Global Fund to Fight AIDS, Tuberculosis and Malaria
- Global Plan to Stop Tuberculosis
- International Congress on Tuberculosis
- International Union Against Tuberculosis and Lung Disease
- Millennium Foundation
- Mycobacterium Tuberculosis Structural Genomics Consortium
- National Jewish Health
- Phipps Institute for the Study, Treatment and Prevention of Tuberculosis
- Stop TB Partnership
- TB Alliance
- Unitaid
- Tuberculosis elimination
- 2007 tuberculosis scare
- Baumgarten-Tangl law
- CFP-10
- ESAT-6
- Iowa Cow War
- List of tuberculosis cases
- Plombage
- Preventorium
- Sanatorium
- Sunshine Way
- Tuberculosis classification
- Tuberculosis in China
- Tuberculosis in human culture
- Tuberculosis radiology
- Tygerberg score
- World Tuberculosis Day