Kopexil

Kopexil
Names
IUPAC names
2,3-Dihydro-3-hydroxy-2-imino-4-pyrimidinamine
2,4-Diaminopyrimidine 3-N-oxide
Other names
Aminexil
Identifiers
CAS Number
  • 113275-13-1 checkY
  • 74638-76-9 (pyridine oxide tautomer) checkY
3D model (JSmol)
  • Interactive image
ChemSpider
  • 10445922
EC Number
  • 616-121-2
PubChem CID
  • 10197687
UNII
  • 1756681479
CompTox Dashboard (EPA)
  • DTXSID40996155 Edit this at Wikidata
InChI
  • InChI=1S/C4H6N4O/c5-3-1-2-7-4(6)8(3)9/h1-2H,5H2,(H2,6,7)
    Key: SGHQFNHCCOBUKB-UHFFFAOYSA-N
  • InChI=1S/C4H6N4O/c5-3-1-2-7-4(6)8(3)9/h1-2,6,9H,5H2
    Key: YTKGAYFHUZTLCI-UHFFFAOYSA-N
  • c1cnc([n+](c1N)[O-])N
Properties
Chemical formula
 C4H6N4O
Molar mass 126.119 g·mol−1
Appearance white odorless crystals[1]
Melting point 210 to 218 °C (410 to 424 °F; 483 to 491 K)[1]
Solubility in water
 slightly soluble[1]
Hazards
GHS labelling:
Pictograms
 GHS07: Exclamation mark
Warning
Hazard statements
 H302
Precautionary statements
 P264, P270, P301+P312, P330, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Chemical compound

Kopexil (INCI name diaminopyrimidine oxide, trade name Aminexil) is a chemical compound similar to minoxidil. Minoxidil was originally used to treat high blood pressure; a side effect was increased body hair. Both compounds have been used for therapy of alopecia.[2] Kopexil is not approved for use as a drug in the United States or in Europe.

Chemical structure

Kopexil is an N-oxide, a group of substances in which the nitrogen atom of a tertiary amine is oxidized. The compound can exist in two tautomeric forms.

Mechanism of action

The exact mechanism of action of kopexil is unknown. There is no proof of therapeutic effect for kopexil against alopecia.[3]

References

  1. ^ a b c MSDS for Kopexil at Kumar Organics. Archived 2015-07-22 at the Wayback Machine March 28th 2012.
  2. ^ Trüeb RM, de Viragh PA: Status of scalp hair and therapy of alopecia in men in Switzerland; PMID 11256223.
  3. ^ Wolfgang Raab: Haarerkrankungen in der dermatologischen Praxis, p. 82, at Google Books (German).



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