HPSE2

Enzyme found in humans
HPSE2
Identifiers
AliasesHPSE2, HPA2, HPR2, UFS, UFS1, heparanase 2 (inactive)
External IDsOMIM: 613469 MGI: 2685814 HomoloGene: 19680 GeneCards: HPSE2
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for HPSE2
Genomic location for HPSE2
Band10q24.2Start98,457,077 bp[1]
End99,235,862 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for HPSE2
Genomic location for HPSE2
Band19|19 C3Start42,774,978 bp[2]
End43,376,794 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • canal of the cervix

  • gastric mucosa

  • popliteal artery

  • hypothalamus

  • caudate nucleus

  • putamen

  • substantia nigra

  • vagina

  • ascending aorta
Top expressed in
  • pineal gland

  • spermatid

  • hand

  • urinary bladder

  • lip

  • morula

  • abdominal wall

  • ileum

  • spermatocyte

  • foot
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • heparan sulfate proteoglycan binding
  • heparanase activity
  • hydrolase activity, acting on glycosyl bonds
Cellular component
  • extracellular region
  • plasma membrane
  • intracellular anatomical structure
  • membrane
  • extracellular matrix
Biological process
  • glycosaminoglycan catabolic process
  • positive regulation of cell population proliferation
  • extracellular matrix organization
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

60495

545291

Ensembl

ENSG00000172987

ENSMUSG00000074852

UniProt

Q8WWQ2

B2RY83

RefSeq (mRNA)

NM_001166244
NM_001166245
NM_001166246
NM_021828

NM_001081257

RefSeq (protein)

NP_001159716
NP_001159717
NP_001159718
NP_068600

NP_001074726

Location (UCSC)Chr 10: 98.46 – 99.24 MbChr 19: 42.77 – 43.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heparanase-2 is an enzyme that in humans is encoded by the HPSE2 gene.[5][6]


It may be associated with urofacial syndrome.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172987 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074852 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McKenzie E, Tyson K, Stamps A, Smith P, Turner P, Barry R, Hircock M, Patel S, Barry E, Stubberfield C, Terrett J, Page M (Oct 2000). "Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member". Biochem Biophys Res Commun. 276 (3): 1170–7. doi:10.1006/bbrc.2000.3586. PMID 11027606.
  6. ^ "Entrez Gene: HPSE2 heparanase 2".
  7. ^ Daly SB, Urquhart JE, Hilton E, et al. (June 2010). "Mutations in HPSE2 Cause Urofacial Syndrome". Am J Hum Genet. 86 (6): 963–969. doi:10.1016/j.ajhg.2010.05.006. PMC 3032078. PMID 20560210.

Further reading

  • D'Souza SS, Fazleabas AT, Banerjee P, et al. (2008). "Decidual heparanase activity is increased during pregnancy in the baboon (Papio anubis) and in in vitro decidualization of human stromal cells". Biol. Reprod. 78 (2): 316–23. doi:10.1095/biolreprod.107.063891. PMID 17989358. S2CID 32383560.
  • Bar-Sela G, Kaplan-Cohen V, Ilan N, et al. (2006). "Heparanase expression in nasopharyngeal carcinoma inversely correlates with patient survival". Histopathology. 49 (2): 188–93. doi:10.1111/j.1365-2559.2006.02469.x. PMID 16879396. S2CID 46173868.
  • Beckhove P, Helmke BM, Ziouta Y, et al. (2005). "Heparanase expression at the invasion front of human head and neck cancers and correlation with poor prognosis". Clin. Cancer Res. 11 (8): 2899–906. doi:10.1158/1078-0432.CCR-04-0664. PMID 15837740. S2CID 22489633.
  • Ogishima T, Shiina H, Breault JE, et al. (2005). "Increased heparanase expression is caused by promoter hypomethylation and up-regulation of transcriptional factor early growth response-1 in human prostate cancer". Clin. Cancer Res. 11 (3): 1028–36. doi:10.1158/1078-0432.1028.11.3. PMID 15709168.
  • Wang Z, Xu H, Jiang L, et al. (2005). "Positive association of heparanase expression with tumor invasion and lymphatic metastasis in gastric carcinoma". Mod. Pathol. 18 (2): 205–11. doi:10.1038/modpathol.3800282. PMID 15475937.
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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