Gluconolactonase

gluconolactonase
Gluconolactonase homodimer, Xanthomonas campestris
Identifiers
EC no.	3.1.1.17
CAS no.	9012-73-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The enzyme gluconolactonase (EC 3.1.1.17) catalyzes the reaction

D-glucono-1,5-lactone + H₂O ${\displaystyle \rightleftharpoons }$ D-gluconate

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is D-glucono-1,5-lactone lactonohydrolase. Other names in common use include lactonase, aldonolactonase, glucono-δ-lactonase, and gulonolactonase. This enzyme participates in three metabolic pathways: pentose phosphate pathway, ascorbate and aldarate metabolism, and caprolactam degradation.

References

• BRODIE AF, LIPMANN F (1955). "Identification of a gluconolactonase". J. Biol. Chem. 212 (2): 677–85. PMID 14353869.
• Bublitz C; Lehninger AL (1961). "The role of aldonolactonase in the conversion of L-gulonate to L-ascorbate". Biochim. Biophys. Acta. 47 (2): 288–297. doi:10.1016/0006-3002(61)90289-X.
• Suzuki K, Kawada M, Shimazono N. "Soluble lactonase. Identity of lactonase I and aldonolactonase with gluconolactonase". J. Biochem. 49: 448–449.