G protein nucleolar 3 like

Protein-coding gene in the species Homo sapiens
GNL3L
Identifiers
AliasesGNL3L, GNL3B, G protein nucleolar 3 like
External IDsOMIM: 300873; MGI: 2448557; HomoloGene: 134538; GeneCards: GNL3L; OMA:GNL3L - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for GNL3L
Genomic location for GNL3L
BandXp11.22Start54,530,183 bp[1]
End54,621,521 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for GNL3L
Genomic location for GNL3L
BandX|X F3Start149,766,137 bp[2]
End149,800,318 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • nipple

  • sural nerve

  • pylorus

  • urethra

  • bone marrow cells

  • human penis

  • renal medulla

  • superior surface of tongue

  • monocyte

  • oral cavity
Top expressed in
  • dorsomedial hypothalamic nucleus

  • paraventricular nucleus of hypothalamus

  • ventral tegmental area

  • habenula

  • suprachiasmatic nucleus

  • arcuate nucleus

  • piriform cortex

  • lateral hypothalamus

  • dorsal tegmental nucleus

  • mammillary body
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • nucleotide binding
  • GTP binding
  • RNA binding
  • GTPase activity
Cellular component
  • nucleus
  • telomerase holoenzyme complex
  • membrane
  • nucleolus
  • cytosol
Biological process
  • regulation of protein stability
  • negative regulation of telomere maintenance via telomerase
  • positive regulation of protein homodimerization activity
  • negative regulation of protein sumoylation
  • positive regulation of protein localization to chromosome, telomeric region
  • negative regulation of protein ubiquitination
  • negative regulation of protein binding
  • ribosome biogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54552

237107

Ensembl

ENSG00000130119

ENSMUSG00000025266

UniProt

Q9NVN8

Q6PGG6

RefSeq (mRNA)

NM_001184819
NM_019067

NM_001168600
NM_198110

RefSeq (protein)

NP_001171748
NP_061940

NP_001162071
NP_932778

Location (UCSC)Chr X: 54.53 – 54.62 MbChr X: 149.77 – 149.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

G protein nucleolar 3 like is a protein that in humans is encoded by the GNL3L gene.[5]

Function

The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130119 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025266 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: G protein nucleolar 3 like". Retrieved 2017-10-23.

Further reading

  • Du X, Rao MR, Chen XQ, Wu W, Mahalingam S, Balasundaram D (2006). "The homologous putative GTPases Grn1p from fission yeast and the human GNL3L are required for growth and play a role in processing of nucleolar pre-rRNA". Mol. Biol. Cell. 17 (1): 460–74. doi:10.1091/mbc.E05-09-0848. PMC 1345682. PMID 16251348.
  • Rao MR, Kumari G, Balasundaram D, Sankaranarayanan R, Mahalingam S (2006). "A novel lysine-rich domain and GTP binding motifs regulate the nucleolar retention of human guanine nucleotide binding protein, GNL3L". J. Mol. Biol. 364 (4): 637–54. doi:10.1016/j.jmb.2006.09.007. PMID 17034816.
  • Oktar PA, Yildirim S, Balci D, Can A (2011). "Continual expression throughout the cell cycle and downregulation upon adipogenic differentiation makes nucleostemin a vital human MSC proliferation marker". Stem Cell Rev. 7 (2): 413–24. doi:10.1007/s12015-010-9201-y. PMID 21063916. S2CID 1002010.
  • Meng L, Hsu JK, Tsai RY (2011). "GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest". Oncogene. 30 (14): 1716–26. doi:10.1038/onc.2010.550. PMC 3072457. PMID 21132010.
  • Lin T, Meng L, Lin TC, Wu LJ, Pederson T, Tsai RY (2014). "Nucleostemin and GNL3L exercise distinct functions in genome protection and ribosome synthesis, respectively". J. Cell Sci. 127 (Pt 10): 2302–12. doi:10.1242/jcs.143842. PMC 6519424. PMID 24610951.
  • Thoompumkal IJ, Subba Rao MR, Kumaraswamy A, Krishnan R, Mahalingam S (2015). "GNL3L Is a Nucleo-Cytoplasmic Shuttling Protein: Role in Cell Cycle Regulation". PLOS ONE. 10 (8): e0135845. Bibcode:2015PLoSO..1035845T. doi:10.1371/journal.pone.0135845. PMC 4537249. PMID 26274615.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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