GABAergic

Affecting GABA systems in the brain

In molecular biology and physiology, something is GABAergic or GABAnergic if it pertains to or affects the neurotransmitter gamma-aminobutyric acid (GABA). For example, a synapse is GABAergic if it uses GABA as its neurotransmitter, and a GABAergic neuron produces GABA. A substance is GABAergic if it produces its effects via interactions with the GABA system, such as by stimulating or blocking neurotransmission.

A GABAergic or GABAnergic agent is any chemical that modifies the effects of GABA in the body or brain. Some different classes of GABAergic drugs include agonists, antagonists, modulators, reuptake inhibitors and enzymes.[1]

See also

  • Adenosinergic
  • Adrenergic
  • Cannabinoidergic
  • Cholinergic
  • Dopaminergic
  • Glutamatergic
  • Glycinergic
  • Histaminergic
  • Melatonergic
  • Monoaminergic
  • Neurotransmission
  • Opioidergic
  • Serotonergic

References

  1. ^ Froestl, Wolfgang (2011). "An historical perspective on GABAergic drugs". Future Medicinal Chemistry. 3 (2): 163–175. doi:10.4155/fmc.10.285. ISSN 1756-8919. PMID 21428811.
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GABA receptor modulators
Ionotropic
GABAATooltip γ-Aminobutyric acid A receptor
GABAATooltip γ-Aminobutyric acid A-rho receptor
Metabotropic
GABABTooltip γ-Aminobutyric acid B receptor
See also
Receptor/signaling modulators
GABAA receptor positive modulators
GABA metabolism/transport modulators
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Types
Classes
Enzyme
see Enzyme inhibition
Ion channel
See Ion channel modulators
Receptor &
transporter
BA/M
Adrenergic
Dopaminergic
Histaminergic
Serotonergic
AA
GABAergic
Glutamatergic
Cholinergic
Cannabinoidergic
Opioidergic
Other
Miscellaneous
  • Cofactor (see Enzyme cofactors)
  • Precursor (see Amino acids)


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