Fluoroacetamide : Wikipedia, the free encyclopedia

Fluoroacetamide

Fluoroacetamide
Names


IUPAC name 2-Fluoroacetamide
Identifiers
CAS Number	640-19-7^Y
3D model (JSmol)	Interactive image Interactive image
ChEBI	CHEBI:53124^Y
ChEMBL	ChEMBL160811^Y
ChemSpider	12025^Y
ECHA InfoCard	100.010.331
KEGG	C18675^N
PubChem CID	12542
UNII	B18R611M38^Y
CompTox Dashboard (EPA)	DTXSID2034255
InChI InChI=1S/C2H4FNO/c3-1-2(4)5/h1H2,(H2,4,5)^Y Key: FVTWJXMFYOXOKK-UHFFFAOYSA-N^Y InChI=1/C2H4FNO/c3-1-2(4)5/h1H2,(H2,4,5) Key: FVTWJXMFYOXOKK-UHFFFAOYAA
SMILES C(C(=O)N)F FCC(=O)N
Properties
Chemical formula	FCH₂CONH₂
Molar mass	77.058 g·mol⁻¹
Appearance	Colorless crystals
Melting point	107 to 109 °C (225 to 228 °F; 380 to 382 K)
Solubility in water	Soluble
Hazards
Occupational safety and health (OHS/OSH):
Main hazards	Very toxic
GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H300+H310
Precautionary statements	P262, P264, P270, P280, P301+P310+P330, P302, P350, P362, P405, P501
NFPA 704 (fire diamond)	4 1
Lethal dose or concentration (LD, LC):
LD₅₀ (median dose)	80 mg/kg (dermal, rat)
LC₅₀ (median concentration)	550 mg/m³(mouse, inhalation, dust/mist)
Safety data sheet (SDS)	^[1]
Related compounds
Related compounds	Chloroacetamide Bromoacetamide Iodoacetamide Fluoroacetic acid Acetamide
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references

Chemical compound

Fluoroacetamide is an organic compound with the chemical formula F C H₂CO NH₂. It is a compound based on acetamide with one fluorine atom replacing hydrogen on the methyl group. It is very toxic.^[1] It is a metabolic poison which disrupts the citric acid cycle and was used as a rodenticide.^[2] May cause reproductive disorders. If swallowed or in contact with skin, it can cause serious damage and death. Can cause serious eye damage.^[1]

References

^ ^a ^b ^c https://www.sigmaaldrich.com/US/en/sds/aldrich/128341?userType=anonymous
^ MATSUMURA F, O'BRIEN RD. A COMPARATIVE STUDY OF THE MODES OF ACTION OF FLUOROACETAMIDE AND FLUOROACETATE IN THE MOUSE AND AMERICAN COCKROACH. Biochem Pharmacol. 1963 Oct;12:1201-5.doi:10.1016/0006-2952(63)90095-9 PMID 14074120

Pest control: Rodenticides

Anticoagulants /
Vitamin K antagonists

Coumarins /
4-Hydroxycoumarins

1st generation	Warfarin Coumatetralyl Fumarin
2nd generation (Superwarfarins)	Brodifacoum Bromadiolone Difenacoum Difethialone Flocoumafen

Phosacetim

Carbamates

Others

v t e Derivatives of fluoroacetic acid and 2-fluoroethanol
Fluoroacetate salts	Aluminum fluoroacetate Ammonium fluoroacetate Barium fluoroacetate Cadmium fluoroacetate Calcium fluoroacetate Cupric fluoroacetate Potassium fluoroacetate Sodium fluoroacetate Thallous fluoroacetate Triethyllead fluoroacetate
Fluoroacetate esters	Allyl fluoroacetate Butyl fluoroacetate Cetyl fluoroacetate Cholesteryl fluoroacetate Ethyl fluoroacetate 2-Ethylhexyl fluoroacetate Fluoroacetylcholine Fluoroaspirin Fluoroethyl fluoroacetate Isopropyl fluoroacetate Methyl fluoroacetate Methylene bis(fluoroacetate) Phenyl fluoroacetate Propyl fluoroacetate
Fluoroethyl esters	Bis(2-fluoroethyl) carbonate Bis(2-fluoroethyl) hydrogen phosphite Bis(2-fluoroethyl) phosphorofluoridate Bis(2-fluoroethyl) sulfate Bis(2-fluoroethyl) sulfite Fluenetil Fluoroethyl acetate Fluoroethyl chloroacetate Fluoroethyl chloroformate Fluoroethyl chlorosulfonate Fluoroethyl fluoroacetate Fluoroethyl nitrite Fluoroethyl trichloroacetate Tetrakis(2-fluoroethyl) orthosilicate TL-790 TL-821 Tris(2-fluoroethyl) arsenite Tris(2-fluoroethyl) borate Tris(2-fluoroethyl) phosphite Tris(2-fluoroethyl) orthoformate
Fluoroacetamides	Fluoroacetamide Fluoroacetanilide Nissol
Other	Bis(2-fluoroethyl)ether 2-chloroethyl fluorothioacetate Fluoroacetic anhydride Fluoroacetyl chloride Fluoroacetyl fluoride