Dinoxyline
Chemical compound
- none
- 8,9-dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,-de]isoquinoline
- 757176-96-8
Y
- 9819126
- 7994875
- 9T7B8CV47A
- Interactive image
- c3ccc(Oc24)c1c3CNCC1c4ccc(O)c2O
InChI
- InChI=1S/C15H13NO3/c17-11-5-4-9-10-7-16-6-8-2-1-3-12(13(8)10)19-15(9)14(11)18/h1-5,10,16-18H,6-7H2
- Key:QOHSTVKJXZTEOL-UHFFFAOYSA-N
Dinoxyline is a synthetic compound developed for scientific research, which acts as a potent full agonist at all five dopamine receptor subtypes.[1][2][3]
References
- ^ Grubbs RA, Lewis MM, Owens-Vance C, Gay EA, Jassen AK, Mailman RB, Nichols DE (March 2004). "8,9-dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,-de]isoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms". Bioorganic & Medicinal Chemistry. 12 (6): 1403–12. doi:10.1016/j.bmc.2004.01.008. PMID 15018913.
- ^ Ryman-Rasmussen JP, Nichols DE, Mailman RB (October 2005). "Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists". Molecular Pharmacology. 68 (4): 1039–48. doi:10.1124/mol.105.012153. PMID 15985612. S2CID 14398107.
- ^ Zhang J, Xiong B, Zhen X, Zhang A (March 2009). "Dopamine D1 receptor ligands: where are we now and where are we going". Medicinal Research Reviews. 29 (2): 272–94. doi:10.1002/med.20130. PMID 18642350. S2CID 25334596.
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Dopamine receptor modulators
- See also: Receptor/signaling modulators
- Adrenergics
- Serotonergics
- Monoamine reuptake inhibitors
- Monoamine releasing agents
- Monoamine metabolism modulators
- Monoamine neurotoxins
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