DPYSL2

Protein-coding gene in the species Homo sapiens

DPYSL2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2GSE, 2VM8

Identifiers

Aliases

DPYSL2, CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2, dihydropyrimidinase like 2

External IDs

OMIM: 602463; MGI: 1349763; HomoloGene: 74392; GeneCards: DPYSL2; OMA:DPYSL2 - orthologs

Gene location (Human)

Chr.	Chromosome 8 (human)^[1]

Band	8p21.2	Start	26,514,031 bp^[1]
Band	8p21.2	End	26,658,178 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)^[2]

Band	14 D1\|14 34.6 cM	Start	67,040,313 bp^[2]
Band	14 D1\|14 34.6 cM	End	67,106,137 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

inferior ganglion of vagus nerve

pars reticulata

subthalamic nucleus

Pars compacta

superior vestibular nucleus

external globus pallidus

pons

cerebellar vermis

lateral nuclear group of thalamus

paraflocculus of cerebellum

Top expressed in

paraventricular nucleus of hypothalamus

globus pallidus

anterior amygdaloid area

habenula

medial geniculate nucleus

dorsomedial hypothalamic nucleus

ventral tegmental area

medial dorsal nucleus

anterior horn of spinal cord

subiculum

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	microtubule binding dihydropyrimidinase activity protein binding hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds hydrolase activity identical protein binding
Cellular component	cytoplasm cytosol membrane extracellular exosome microtubule cytoskeleton plasma membrane
Biological process	regulation of neuron differentiation cell differentiation endocytosis regulation of axon extension nervous system development multicellular organism development brain development cytoskeleton organization nucleobase-containing compound metabolic process signal transduction axon guidance pyrimidine nucleobase catabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1808


12934

Ensembl


ENSG00000092964


ENSMUSG00000022048

UniProt


Q16555


O08553

RefSeq (mRNA)


NM_001386 NM_001197293 NM_001244604


NM_009955 NM_001378767

RefSeq (protein)


NP_001184222 NP_001231533 NP_001377


NP_034085 NP_001365696

Location (UCSC)

Chr 8: 26.51 – 26.66 Mb

Chr 14: 67.04 – 67.11 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Dihydropyrimidinase-related protein 2 is an enzyme that in humans is encoded by the DPYSL2 gene.^[5]^[6]

Interactions

DPYSL2 has been shown to interact with CRMP1,^[7] Adaptor-related protein complex 2, alpha 1^[8] and NUMB.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000092964 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022048 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.
^ "Entrez Gene: DPYSL2 dihydropyrimidinase-like 2".
^ Leung T, Ng Yvonne, Cheong Albert, Ng Chong Han, Tan Ivan, Hall Christine, Lim Louis (Dec 2002). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. 532 (3). Netherlands: 445–9. doi:10.1016/S0014-5793(02)03736-5. ISSN 0014-5793. PMID 12482610. S2CID 45499981.
^ ^a ^b Nishimura T, Fukata Yuko, Kato Katsuhiro, Yamaguchi Tomoya, Matsuura Yoshiharu, Kamiguchi Hiroyuki, Kaibuchi Kozo (Sep 2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth". Nat. Cell Biol. 5 (9). England: 819–26. doi:10.1038/ncb1039. ISSN 1465-7392. PMID 12942088. S2CID 12118386.

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Kitamura K, Takayama M, Hamajima N, et al. (2000). "Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene". DNA Res. 6 (5): 291–7. doi:10.1093/dnares/6.5.291. PMID 10574455.
Gu Y, Hamajima N, Ihara Y (2000). "Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522". Biochemistry. 39 (15): 4267–75. doi:10.1021/bi992323h. PMID 10757975.
Gu Y, Ihara Y (2000). "Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules". J. Biol. Chem. 275 (24): 17917–20. doi:10.1074/jbc.C000179200. PMID 10770920.
Arimura N, Inagaki N, Chihara K, et al. (2000). "Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse". J. Biol. Chem. 275 (31): 23973–80. doi:10.1074/jbc.M001032200. PMID 10818093.
Fukada M, Watakabe I, Yuasa-Kawada J, et al. (2001). "Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family". J. Biol. Chem. 275 (48): 37957–65. doi:10.1074/jbc.M003277200. PMID 10956643.
Santolini E, Puri C, Salcini AE, et al. (2001). "Numb Is an Endocytic Protein". J. Cell Biol. 151 (6): 1345–52. doi:10.1083/jcb.151.6.1345. PMC 2190585. PMID 11121447.
Lee S, Kim JH, Lee CS, et al. (2002). "Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction". J. Biol. Chem. 277 (8): 6542–9. doi:10.1074/jbc.M108047200. PMID 11741937.
Weitzdoerfer R, Fountoulakis M, Lubec G (2002). "Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down Syndrome brain". Protein Expression in Down Syndrome Brain. pp. 95–107. doi:10.1007/978-3-7091-6262-0_8. ISBN 978-3-211-83704-7. PMID 11771764. {{cite book}}: |journal= ignored (help)
Fukata Y, Itoh TJ, Kimura T, et al. (2002). "CRMP-2 binds to tubulin heterodimers to promote microtubule assembly". Nat. Cell Biol. 4 (8): 583–91. doi:10.1038/ncb825. PMID 12134159. S2CID 22934366.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Leung T, Ng Y, Cheong A, et al. (2003). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. 532 (3): 445–9. doi:10.1016/S0014-5793(02)03736-5. PMID 12482610. S2CID 45499981.
Nishimura T, Fukata Y, Kato K, et al. (2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth". Nat. Cell Biol. 5 (9): 819–26. doi:10.1038/ncb1039. PMID 12942088. S2CID 12118386.
Nakata K, Ujike H, Tanaka Y, et al. (2003). "No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans". Neurosci. Lett. 349 (3): 171–4. doi:10.1016/S0304-3940(03)00824-3. PMID 12951196. S2CID 30637558.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.