DNAJB4

Protein-coding gene in the species Homo sapiens
DNAJB4
Identifiers
AliasesDNAJB4, DNAJW, DjB4, HLJ1, DnaJ heat shock protein family (Hsp40) member B4
External IDsOMIM: 611327; MGI: 1914285; HomoloGene: 100610; GeneCards: DNAJB4; OMA:DNAJB4 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for DNAJB4
Genomic location for DNAJB4
Band1p31.1Start77,979,175 bp[1]
End78,017,964 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for DNAJB4
Genomic location for DNAJB4
Band3|3 H3Start151,884,148 bp[2]
End151,915,939 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Skeletal muscle tissue of rectus abdominis

  • Achilles tendon

  • Skeletal muscle tissue of biceps brachii

  • muscle of thigh

  • right ventricle

  • thoracic diaphragm

  • tail of epididymis

  • myocardium

  • vena cava

  • right coronary artery
Top expressed in
  • ascending aorta

  • aortic valve

  • secondary oocyte

  • zygote

  • seminiferous tubule

  • primary oocyte

  • atrioventricular valve

  • spermatid

  • intercostal muscle

  • tunica media of zone of aorta
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • unfolded protein binding
  • chaperone binding
  • protein binding
  • ATPase activator activity
Cellular component
  • cytosol
  • membrane
  • cytoplasm
  • nucleoplasm
  • plasma membrane
Biological process
  • response to unfolded protein
  • response to heat
  • protein folding
  • positive regulation of ATP-dependent activity
  • negative regulation of transcription by RNA polymerase II
  • chaperone cofactor-dependent protein refolding
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11080

67035

Ensembl

ENSG00000162616

ENSMUSG00000028035

UniProt

Q9UDY4

Q9D832

RefSeq (mRNA)
NM_007034
NM_001317099
NM_001317100
NM_001317101
NM_001317102

NM_001317103

NM_025926
NM_027287
NM_001356363
NM_001356364

RefSeq (protein)
NP_001304028
NP_001304029
NP_001304030
NP_001304031
NP_001304032

NP_008965

NP_080202
NP_081563
NP_001343292
NP_001343293

Location (UCSC)Chr 1: 77.98 – 78.02 MbChr 3: 151.88 – 151.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DnaJ homolog subfamily B member 4 is a protein that in humans is encoded by the DNAJB4 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162616 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028035 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hoe KL, Won M, Chung KS, Jang YJ, Lee SB, Kim DU, Lee JW, Yun JH, Yoo HS (Apr 1998). "Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40) from human liver". Biochim Biophys Acta. 1383 (1): 4–8. doi:10.1016/s0167-4838(97)00207-0. PMID 9546042.
  6. ^ Ohtsuka K, Hata M (Jan 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress & Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 2024-03-28). ISSN 1466-1268. PMC 312896. PMID 11147971.{{cite journal}}: CS1 maint: DOI inactive as of March 2024 (link)
  7. ^ "Entrez Gene: DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Borges JC, Fischer H, Craievich AF, Ramos CH (2005). "Low resolution structural study of two human HSP40 chaperones in solution. DJA1 from subfamily A and DJB4 from subfamily B have different quaternary structures". J. Biol. Chem. 280 (14): 13671–81. doi:10.1074/jbc.M408349200. PMID 15661747.
  • Wang CC, Tsai MF, Hong TM, et al. (2005). "The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion". Oncogene. 24 (25): 4081–93. doi:10.1038/sj.onc.1208573. PMID 15782117.
  • Ancevska-Taneva N, Onoprishvili I, Andria ML, et al. (2006). "A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor". Brain Res. 1081 (1): 28–33. doi:10.1016/j.brainres.2006.01.125. PMID 16542645. S2CID 42100583.
  • Tsai MF, Wang CC, Chang GC, et al. (2006). "A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma". J. Natl. Cancer Inst. 98 (12): 825–38. doi:10.1093/jnci/djj229. PMID 16788156.
  • v
  • t
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Chaperones/
protein folding
Heat shock proteins/
Chaperonins
Other
Protein targetingUbiquitin
(ubiquitylation)Ubiquitin-like proteins
(UBL)
SUMO protein
(SUMOylation)
  • E1 SUMO-activating enzyme
  • E2 SUMO-conjugating enzyme
Other


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