Carboxy-cis,cis-muconate cyclase
carboxy-cis,cis-muconate cyclase | |||||||||
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Identifiers | |||||||||
EC no. | 5.5.1.5 | ||||||||
CAS no. | 37318-55-1 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a carboxy-cis,cis-muconate cyclase (EC 5.5.1.5) is an enzyme that catalyzes the chemical reaction
- 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate 3-carboxy-cis,cis-muconate
Hence, this enzyme has one substrate, 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate, and one product, 3-carboxy-cis,cis-muconate.
This enzyme belongs to the family of isomerases, specifically the class of intramolecular lyases. The systematic name of this enzyme class is 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing). This enzyme is also called 3-carboxymuconate cyclase. This enzyme participates in benzoate degradation via hydroxylation.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1JOF.
References
- GROSS SR, GAFFORD RD, TATUM EL (1956). "The metabolism of protocatechuic acid by Neurospora". J. Biol. Chem. 219 (2): 781–96. PMID 13319299.
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- t
- e
- muconate cycloisomerase
- 3-carboxy-cis,cis-muconate cycloisomerase
- tetrahydroxypteridine cycloisomerase
- inositol-3-phosphate synthase
- carboxy-cis,cis-muconate cyclase
- chalcone isomerase
- chloromuconate cycloisomerase
- bornyl diphosphate synthase
- cycloeucalenol cycloisomerase
- a-pinene-oxide decyclase
- dichloromuconate cycloisomerase
- copalyl diphosphate synthase
- ent-copalyl diphosphate synthase
- syn-copalyl-diphosphate synthase
- terpentedienyl-diphosphate synthase
- halimadienyl-diphosphate synthase
- (S)-beta-macrocarpene synthase
- lycopene epsilon-cyclase
- lycopene beta-cyclase
- prosolanapyrone-III cycloisomerase
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- v
- t
- e