CPSF3

Protein-coding gene in humans

CPSF3

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2I7T, 2I7V

Identifiers

Aliases

CPSF3, CPSF-73, CPSF73, cleavage and polyadenylation specific factor 3

External IDs

OMIM: 606029; MGI: 1859328; HomoloGene: 6499; GeneCards: CPSF3; OMA:CPSF3 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2p25.1	Start	9,423,651 bp^[1]
Band	2p25.1	End	9,473,101 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12\|12 A1.3	Start	21,335,392 bp^[2]
Band	12\|12 A1.3	End	21,365,057 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

ventricular zone

left testis

right testis

endothelial cell

tendon of biceps brachii

sperm

monocyte

stromal cell of endometrium

islet of Langerhans

Top expressed in

primitive streak

medullary collecting duct

ureter

internal carotid artery

condyle

fossa

vas deferens

Epithelium of choroid plexus

external carotid artery

endothelial cell of lymphatic vessel

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	5'-3' exonuclease activity metal ion binding endoribonuclease activity protein binding RNA binding nuclease activity endonuclease activity hydrolase activity
Cellular component	mRNA cleavage and polyadenylation specificity factor complex nucleoplasm nucleus
Biological process	mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA 3'-end processing by stem-loop binding and cleavage mRNA processing mRNA export from nucleus mRNA polyadenylation mRNA cleavage mRNA 3'-end processing RNA phosphodiester bond hydrolysis, endonucleolytic sno(s)RNA 3'-end processing snoRNA splicing pre-mRNA cleavage required for polyadenylation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


51692


54451

Ensembl


ENSG00000119203


ENSMUSG00000054309

UniProt


Q9UKF6


Q9QXK7

RefSeq (mRNA)


NM_016207 NM_001321833 NM_001321834 NM_001321835 NM_001321836


NM_018813 NM_001364372 NM_001364373

RefSeq (protein)


NP_001308762 NP_001308763 NP_001308764 NP_001308765 NP_057291


NP_061283 NP_001351301 NP_001351302

Location (UCSC)

Chr 2: 9.42 – 9.47 Mb

Chr 12: 21.34 – 21.37 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Cleavage and polyadenylation specificity factor subunit 3 is a protein that in humans is encoded by the CPSF3 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119203 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054309 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jenny A, Minvielle-Sebastia L, Preker PJ, Keller W (Dec 1996). "Sequence similarity between the 73-kilodalton protein of mammalian CPSF and a subunit of yeast polyadenylation factor I". Science. 274 (5292): 1514–7. Bibcode:1996Sci...274.1514J. doi:10.1126/science.274.5292.1514. PMID 8929409. S2CID 12958377.
^ "Entrez Gene: CPSF3 cleavage and polyadenylation specific factor 3, 73kDa".

External links

Human CPSF3 genome location and CPSF3 gene details page in the UCSC Genome Browser.

Murthy KG, Manley JL (1995). "The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation". Genes Dev. 9 (21): 2672–83. doi:10.1101/gad.9.21.2672. PMID 7590244.
Jenny A, Hauri HP, Keller W (1994). "Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit". Mol. Cell. Biol. 14 (12): 8183–90. doi:10.1128/MCB.14.12.8183. PMC 359357. PMID 7969155.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Thuresson AC, Aström J, Aström A, et al. (1994). "Multiple forms of poly(A) polymerases in human cells". Proc. Natl. Acad. Sci. U.S.A. 91 (3): 979–83. Bibcode:1994PNAS...91..979T. doi:10.1073/pnas.91.3.979. PMC 521437. PMID 8302877.
McCracken S, Fong N, Yankulov K, et al. (1997). "The C-terminal domain of RNA polymerase II couples mRNA processing to transcription". Nature. 385 (6614): 357–61. Bibcode:1997Natur.385..357M. doi:10.1038/385357a0. PMID 9002523. S2CID 4307073.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Takagaki Y, Manley JL (2000). "Complex protein interactions within the human polyadenylation machinery identify a novel component". Mol. Cell. Biol. 20 (5): 1515–25. doi:10.1128/MCB.20.5.1515-1525.2000. PMC 85326. PMID 10669729.
de Vries H, Rüegsegger U, Hübner W, et al. (2000). "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors". EMBO J. 19 (21): 5895–904. doi:10.1093/emboj/19.21.5895. PMC 305781. PMID 11060040.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kaufmann I, Martin G, Friedlein A, et al. (2005). "Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase". EMBO J. 23 (3): 616–26. doi:10.1038/sj.emboj.7600070. PMC 1271804. PMID 14749727.
Calzado MA, Sancho R, Muñoz E (2004). "Human immunodeficiency virus type 1 Tat increases the expression of cleavage and polyadenylation specificity factor 73-kilodalton subunit modulating cellular and viral expression". J. Virol. 78 (13): 6846–54. doi:10.1128/JVI.78.13.6846-6854.2004. PMC 421638. PMID 15194760.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mandel CR, Kaneko S, Zhang H, et al. (2007). "Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease". Nature. 444 (7121): 953–6. doi:10.1038/nature05363. PMC 3866582. PMID 17128255.
de la Vega L, Sánchez-Duffhues G, Fresno M, et al. (2007). "The 73 kDa subunit of the CPSF complex binds to the HIV-1 LTR promoter and functions as a negative regulatory factor that is inhibited by the HIV-1 Tat protein". J. Mol. Biol. 372 (2): 317–30. doi:10.1016/j.jmb.2007.06.075. PMID 17669424.