Bethanidine : Wikipedia, the free encyclopedia

Bethanidine

Chemical compound

Identifiers

CAS Number

PubChem CID

IUPHAR/BPS

DrugBank

ChemSpider

UNII

KEGG

ChEBI

ChEMBL

CompTox Dashboard (EPA)

Chemical and physical dataFormulaC₁₀H₁₅N₃Molar mass177.251 g·mol⁻¹3D model (JSmol)

InChI

InChI=1S/C10H15N3/c1-11-10(12-2)13-8-9-6-4-3-5-7-9/h3-7H,8H2,1-2H3,(H2,11,12,13)^Y
Key:NIVZHWNOUVJHKV-UHFFFAOYSA-N^Y

^NY (what is this?) (verify)

Bethanidine (or betanidine) is a sympatholytic drug.^[1]

References

^ Prichard BN, Johnston AW, Hill ID, Rosenheim ML (January 1968). "Bethanidine, Guanethidine, and Methyldopa in Treatment of Hypertension: a Within-patient Comparison". British Medical Journal. 1 (5585): 135–44. doi:10.1136/bmj.1.5585.135. PMC 1984601. PMID 20791420.

Sympatholytic (and closely related) antihypertensives (C02)

Central

α₂-Adrenergic receptor agonists	Clonidine Guanabenz Guanfacine Guanoxabenz Methyldopa^# Tiamenidine^‡
Adrenergic release inhibitors	Bethanidine Bretylium Debrisoquine Guanadrel Guanazodine Guancydine Guanethidine Guanoclor Guanoxan
Imidazoline receptor agonists	Moxonidine Rilmenidine Tolonidine
Ganglion-blocking/nicotinic antagonists	Hexamethonium^‡ Mecamylamine Pentolinium Trimethaphan

Peripheral

Indirect

Monoamine oxidase inhibitors	Pargyline^‡
VMAT inhibitors	Bietaserpine Deserpidine Methoserpidine Reserpine Syrosingopine
Tyrosine hydroxylase inhibitors	Metirosine

Direct

α₁-Adrenergic receptor blockers	Doxazosin Ketanserin Indoramin Prazosin Trimazosin Urapidil
Non-selective α-adrenergic receptor blockers	Phentolamine

Serotonin receptor antagonists	Ketanserin Lidanserin
Endothelin receptor antagonists (for PHTooltip Pulmonary hypertension)	dual (Aprocitentan, Bosentan, Macitentan (+tadalafil)) selective (Ambrisentan, Sitaxentan)