BET1

Protein-coding gene in the species Homo sapiens
BET1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3EGX

Identifiers
AliasesBET1, HBet1 golgi vesicular membrane trafficking protein
External IDsOMIM: 605456 MGI: 1343104 HomoloGene: 38108 GeneCards: BET1
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for BET1
Genomic location for BET1
Band7q21.3Start93,962,762 bp[1]
End94,004,382 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for BET1
Genomic location for BET1
Band6|6 A1Start4,076,899 bp[2]
End4,086,972 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • Achilles tendon

  • placenta

  • endometrium

  • corpus epididymis

  • anterior pituitary

  • monocyte

  • right adrenal gland

  • left adrenal gland

  • stromal cell of endometrium
Top expressed in
  • lip

  • seminal vesicula

  • lacrimal gland

  • otic placode

  • parotid gland

  • morula

  • left lobe of liver

  • yolk sac

  • fossa

  • jejunum
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • syntaxin binding
  • SNAP receptor activity
Cellular component
  • integral component of membrane
  • Golgi apparatus
  • endoplasmic reticulum membrane
  • membrane
  • Golgi cisterna
  • Golgi membrane
  • cis-Golgi network
  • transport vesicle
  • SNARE complex
  • endoplasmic reticulum
  • endoplasmic reticulum-Golgi intermediate compartment membrane
  • Golgi trans cisterna
  • integral component of Golgi membrane
Biological process
  • vesicle fusion with Golgi apparatus
  • endoplasmic reticulum to Golgi vesicle-mediated transport
  • COPII vesicle coating
  • protein transport
  • vesicle-mediated transport
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10282

12068

Ensembl

ENSG00000105829

ENSMUSG00000032757

UniProt

O15155

O35623

RefSeq (mRNA)

NM_005868
NM_001317739

NM_009748

RefSeq (protein)

NP_001304668
NP_005859

NP_033878

Location (UCSC)Chr 7: 93.96 – 94 MbChr 6: 4.08 – 4.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

BET1 homolog is a protein that in humans is encoded by the BET1 gene.[5][6][7]

This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factor attachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has not been determined.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105829 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032757 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhang T, Wong SH, Tang BL, Xu Y, Peter F, Subramaniam VN, Hong W (Dec 1997). "The mammalian protein (rbet1) homologous to yeast Bet1p is primarily associated with the pre-Golgi intermediate compartment and is involved in vesicular transport from the endoplasmic reticulum to the Golgi apparatus". J Cell Biol. 139 (5): 1157–68. doi:10.1083/jcb.139.5.1157. PMC 2140212. PMID 9382863.
  6. ^ Waters MG, Pfeffer SR (Nov 1999). "Membrane tethering in intracellular transport". Curr Opin Cell Biol. 11 (4): 453–9. doi:10.1016/S0955-0674(99)80065-9. PMID 10449330.
  7. ^ a b "Entrez Gene: BET1 BET1 homolog (S. cerevisiae)".

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zhang T, Hong W (2001). "Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport". J. Biol. Chem. 276 (29): 27480–7. doi:10.1074/jbc.M102786200. PMID 11323436.
  • Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Hay JC, Chao DS, Kuo CS, Scheller RH (1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. PMID 9094723. S2CID 8682509.
  • Hay JC, Hirling H, Scheller RH (1996). "Mammalian vesicle trafficking proteins of the endoplasmic reticulum and Golgi apparatus". J. Biol. Chem. 271 (10): 5671–9. doi:10.1074/jbc.271.10.5671. PMID 8621431.

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