Acid hydrolase

Enzyme

An acid hydrolase is an enzyme that works best at acidic pHs. It is commonly located in lysosomes, which are acidic on the inside. Acid hydrolases may be nucleases, proteases, glycosidases, lipases, phosphatases, sulfatases and phospholipases and make up the approximately 50 degradative enzymes of the lysosome that break apart biological matter.^[1]

types of Acid Hydrolase:

-Nucleases (P1 from Penicillium citrinum, used in the food industry for taste enhancement or present in Gouda cheese)^[2]

-Lipase: for example lysosomal acid lipase.

-Proteases

-Glycosidases

References

^ Molecular Cell Biology 6ed, Lodish et al.
^ Okado, N.; Hasegawa, K.; Mizuhashi, F.; Lynch, B. S.; Vo, T. D.; Roberts, A. S. (2016). "Safety evaluation of nuclease P1 from Penicillium citrinum". Food and Chemical Toxicology. 88: 21–31. doi:10.1016/j.fct.2015.12.001. PMID 26686996.

Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases

Cholinesterase
- Acetylcholinesterase
- Butyrylcholinesterase
Pectinesterase
6-phosphogluconolactonase
PAF acetylhydrolase

Lipase

Phospholipase
- A1
- A2
- B

3.1.2: Thioesterase

3.1.3: Phosphatase

3.1.4:
Phosphodiesterase

3.1.6: Sulfatase

Nuclease (includes
deoxyribonuclease
and ribonuclease)

3.1.11-16:
Exonuclease

Exodeoxyribonuclease	RecBCD
Exoribonuclease	Oligonucleotidase

3.1.21-31:
Endonuclease

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme;see {{Restriction enzyme}} UvrABC endonuclease
Endoribonuclease	RNase III Drosha: Microprocessor complex Dicer: RNA-induced silencing complex RNase H 1 2A 2B 2C RNase P RNase A RNase Z RNase E 1 2 3 4/5 RNase T1
either deoxy- or ribo-	Nuclease S1 Mung bean nuclease Serratia marcescens nuclease Micrococcal nuclease

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)