APOLD1

Protein-coding gene in the species Homo sapiens
APOLD1
Identifiers
AliasesAPOLD1, VERGE, apolipoprotein L domain containing 1
External IDsOMIM: 612456; MGI: 2685921; HomoloGene: 12781; GeneCards: APOLD1; OMA:APOLD1 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for APOLD1
Genomic location for APOLD1
Band12p13.1Start12,725,917 bp[1]
End12,829,975 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for APOLD1
Genomic location for APOLD1
Band6|6 G1Start134,958,681 bp[2]
End134,963,799 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • pericardium

  • thoracic diaphragm

  • lower lobe of lung

  • mucosa of urinary bladder

  • subcutaneous adipose tissue

  • Epithelium of choroid plexus

  • left uterine tube

  • olfactory bulb

  • inferior olivary nucleus
Top expressed in
  • endothelial cell of lymphatic vessel

  • semi-lunar valve

  • retinal pigment epithelium

  • aortic valve

  • islet of Langerhans

  • spermatocyte

  • olfactory bulb

  • ascending aorta

  • atrioventricular valve

  • brown adipose tissue
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • lipid binding
Cellular component
  • extracellular region
  • plasma membrane
  • integral component of membrane
  • membrane
  • nucleoplasm
  • cytosol
Biological process
  • angiogenesis
  • response to hypoxia
  • lipid transport
  • cell differentiation
  • endothelial cell activation
  • lipoprotein metabolic process
  • regulation of endothelial cell differentiation
  • multicellular organism development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

81575

381823

Ensembl

ENSG00000178878

ENSMUSG00000090698

UniProt

Q96LR9

E9Q0X2

RefSeq (mRNA)

NM_030817
NM_001130415

NM_001109914

RefSeq (protein)

NP_001123887
NP_110444

NP_001103384

Location (UCSC)Chr 12: 12.73 – 12.83 MbChr 6: 134.96 – 134.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Apolipoprotein L domain containing 1 is a protein in humans that is encoded by the APOLD1 gene. [5] It is located on Chromosome 12.[6]

APOLD1 is an endothelial cell early response protein that may play a role in regulation of endothelial cell signaling and vascular function (Regard et al., 2004 [PubMed 15102925]).[supplied by OMIM, Dec 2008].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178878 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090698 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Apolipoprotein L domain containing 1". Retrieved 2012-11-02.
  6. ^ APOLD1 apolipoprotein L domain containing 1 [ Homo sapiens (human) ] on NCBI

External links

Further reading


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